Smallest region of overlap in Wilms tumor deletions uniquely implicates an 11p13 zinc finger gene as the disease locus.
Smallest region of overlap in Wilms tumor deletions uniquely implicates an 11p13 zinc finger gene as the disease locus.
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肾母细胞瘤缺失中最小的重叠区域独特地表明 11p13 锌指基因是疾病基因座。
DOI：
10.1016/0888-7543(91)90516-h
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发表时间：
1991
期刊：
影响因子：
4.4
通讯作者：
Grady F. Saunders
中科院分区：
文献类型：
--
作者：
Carl C.T. Ton;Vicki D Huff;Katherine M. Call;Susan L. Cohn;L. Strong;David E. Housman;Grady F. Saunders
肾母细胞瘤（Wilms tumor，WT）的发生与人类11号染色体p13区带中一个“肿瘤抑制基因”位点的失活有关。已经报道了几种表现出11p13候选WT基因整体纯合缺失的WT。我们在这里报告的候选基因的部分缺失，与其他记录的纯合性缺失相比，允许一个精确的定义在肾母细胞瘤的关键基因组靶。这些缺失之间最小的重叠区域是一个16 kb的DNA片段，包含编码锌指蛋白的11p13基因的5′外显子，以及相关的CpG岛。这一发现支持了候选基因对应于11p13WT1Wilms肿瘤位点的观点。
The development of Wilms tumor (WT) has been associated with the inactivation of a “tumor suppressor” locus in human chromosome 11 band p13. Several WTs that exhibit homozygous deletions of an 11p13 candidate WT gene in its entirety have been reported. We report here a partial deletion of the candidate gene which, upon comparison with other documented homozygous deletions, permitted a precise definition of the critical genomic target in Wilms tumor. The smallest region of overlap between these deletions is a 16-kb segment of DNA encompassing the 5′ exon(s) of an 11p13 gene coding for a zinc finger protein, together with an associated CpG island. This finding supports the notion that the candidate gene in question corresponds to the 11p13WT1Wilms tumor locus.
编码 II 类组织相容性抗原的不变伽马链的人类基因的结构。
影响因子：
14.9
作者：
Kudo,J;Chao,LY;Narni,F;Saunders,GF
通讯作者：
Saunders,GF
人类染色体 11p13 上维尔姆斯肿瘤位点界限的定义。
影响因子：
4.4
作者：
Compton,DA;Weil,MM;Bonetta,L;Huang,A;Jones,C;Yeger,H;Williams,BR;Strong,LC;Saunders,GF
通讯作者：
Saunders,GF
影响因子：
56.9
作者：
MURPHREE, AL;BENEDICT, WF
通讯作者：
BENEDICT, WF