Mesenchymal progenitors and the osteoblast lineage in bone marrow hematopoietic niches.

Mesenchymal progenitors and the osteoblast lineage in bone marrow hematopoietic niches.
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间充质祖细胞和骨髓造血壁ni的成骨细胞谱系。

DOI:
10.1007/s11914-014-0190-7
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发表时间:
2014-03
影响因子:
4.3
通讯作者:
Wu, Joy Y.
Wu, Joy Y.
中科院分区:
医学2区
文献类型:
--
作者:
Panaroni, Cristina;Tzeng, Yi-Shiuan;Saeed, Hamid;Wu, Joy Y.

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骨髓腔对于造血系统的正常发育至关重要。在过去的几十年中,已经清楚的是,间充质干/祖细胞以及成骨细胞谱系的细胞,除了维持骨稳态之外,也是骨髓造血的基本调节剂。一些研究已经证明间充质和成骨细胞谱系细胞直接参与维持和调节造血干细胞静止、自我更新和分化所必需的支持性微环境。此外,还在骨髓中鉴定了用于成熟造血细胞的特定小生境。在这里,我们将回顾最近的研究结果,强调了间充质祖细胞和成骨细胞谱系的细胞在调节造血的不同阶段的作用。
The bone marrow cavity is essential for the proper development of the hematopoietic system. In the last few decades it has become clear that mesenchymal stem/progenitor cells as well as cells of the osteoblast lineage, besides maintaining bone homeostasis, are also fundamental regulators of bone marrow hematopoiesis. Several studies have demonstrated the direct involvement of mesenchymal and osteoblast lineage cells in the maintenance and regulation of supportive microenvironments necessary for quiescence, self-renewal and differentiation of hematopoietic stem cells. In addition, specific niches have also been identified within the bone marrow for maturing hematopoietic cells. Here we will review recent findings that have highlighted the roles of mesenchymal progenitors and cells of the osteoblast lineage in regulating distinct stages of hematopoiesis.
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发表时间: 2012-02
期刊: STEM CELLS
影响因子: 5.2
作者:
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