Evaluating the Molecular Properties and Function of ANKHD1, and Its Role in Cancer.
Evaluating the Molecular Properties and Function of ANKHD1, and Its Role in Cancer.
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DOI：
10.3390/ijms241612834
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发表时间：
2023-08-16
影响因子：
5.6
通讯作者：
Fragiadaki, Maria
中科院分区：
文献类型：
--
作者：
Mullenger, Jordan L.;Zeidler, Martin P.;Fragiadaki, Maria
锚蛋白重复序列和含单KH结构域的蛋白1（ANKHD 1）是由介导蛋白质-蛋白质相互作用的两段锚蛋白重复序列结构域和介导RNA或单链DNA结合的KH结构域组成的大型支架蛋白。ANKHD 1与几种关键信号通路中的蛋白质相互作用，包括受体酪氨酸激酶、JAK/STAT、机械敏感性Hippo（雅普/TAZ）和p21。对ANKHD 1在癌细胞系中作用的研究表明，ANKHD 1在驱动不受控制的细胞增殖和生长、增强的致瘤性、通过S期的细胞周期进展以及增加的上皮向间充质转化中起关键作用。此外，在临床水平上，ANKHD 1的表达增加与更大的肿瘤浸润、转移增加和更大的肿瘤相关。升高的ANKHD 1导致预后较差，更具侵略性的生长，以及许多癌症类型患者生存率的降低。本文综述了ANKHD 1的分子生物学特性和功能，重点介绍了该蛋白在细胞和临床水平上对肿瘤的作用。
Ankyrin repeat and single KH domain-containing protein 1 (ANKHD1) is a large, scaffolding protein composed of two stretches of ankyrin repeat domains that mediate protein–protein interactions and a KH domain that mediates RNA or single-stranded DNA binding. ANKHD1 interacts with proteins in several crucial signalling pathways, including receptor tyrosine kinase, JAK/STAT, mechanosensitive Hippo (YAP/TAZ), and p21. Studies into the role of ANKHD1 in cancer cell lines demonstrate a crucial role in driving uncontrolled cellular proliferation and growth, enhanced tumorigenicity, cell cycle progression through the S phase, and increased epithelial-to-mesenchymal transition. Furthermore, at a clinical level, the increased expression of ANKHD1 has been associated with greater tumour infiltration, increased metastasis, and larger tumours. Elevated ANKHD1 resulted in poorer prognosis, more aggressive growth, and a decrease in patient survival in numerous cancer types. This review aims to gather the current knowledge about ANKHD1 and explore its molecular properties and functions, focusing on the protein’s role in cancer at both a cellular and clinical level.
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影响因子：
64.8
作者：
Jumper J;Evans R;Pritzel A;Green T;Figurnov M;Ronneberger O;Tunyasuvunakool K;Bates R;Žídek A;Potapenko A;Bridgland A;Meyer C;Kohl SAA;Ballard AJ;Cowie A;Romera-Paredes B;Nikolov S;Jain R;Adler J;Back T;Petersen S;Reiman D;Clancy E;Zielinski M;Steinegger M;Pacholska M;Berghammer T;Bodenstein S;Silver D;Vinyals O;Senior AW;Kavukcuoglu K;Kohli P;Hassabis D
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影响因子：
4.8
作者：
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影响因子：
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作者：
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