Alternative ANKHD1 transcript promotes proliferation and inhibits migration in uterine corpus endometrial carcinoma.
Alternative ANKHD1 transcript promotes proliferation and inhibits migration in uterine corpus endometrial carcinoma.
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DOI：
10.1038/s41525-022-00321-0
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发表时间：
2022-09-29
影响因子：
5.3
通讯作者：
Ouyang, Yiqin
中科院分区：
文献类型：
--
作者：
Sun, Wenhuizi;Huang, Runzhi;Li, Zhenyu;Zhu, Yaru;Bai, Yan;Wu, Siyu;Wang, Jingshuai;Xiao, Yan;Xian, Shuyuan;Tong, Xiaowen;Zhang, Jie;Guo, Yi;Ouyang, Yiqin
选择性剪接(AS)在基因表达中很常见，异常剪接经常导致几种癌症。总体生存相关剪接事件(OS-SE)已被用于预测癌症的预后。本研究旨在探讨OS-Ses在子宫内膜癌(UCEC)中的表达及功能。基于TCGA和TCGASpliceSeq数据库，检索UCEC样本的基因表达和AS数据。ANKHD1转录本的另一个终止子ANKHD1-BP3被发现与UCEC的转移和OS显著相关，与HSPB1显著相关。HSPB1表达上调导致ANKHD1-BP3表达下调，促进肿瘤转移。这些结果表明，HSPB1是一种剪接因子，调节ANKHD1-BP3的表达，促进UCEC的转移。
Alternative splicing (AS) is common in gene expression, and abnormal splicing often results in several cancers. Overall survival-associated splicing events (OS-SEs) have been used to predict prognosis in cancer. The aim of this study was to investigate the presence and function of OS-SEs in uterine corpus endometrial carcinoma (UCEC). Based on TCGA and TCGASpliceSeq databases, gene expression and the AS data of UCEC samples were retrieved. An alternate terminator of ANKHD1 transcripts named ANKHD1-BP3 was found to be significantly related to metastasis and OS in UCEC and significantly associated with HSPB1. The upregulated expression of HSPB1 induced downregulation of ANKHD1-BP3 and promoted tumor metastasis. These findings indicate that HSPB1, a splicing factor, regulates the expression of ANKHD1-BP3 to promote metastasis in UCEC.
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DOI：
10.1038/nrm.2017.27
发表时间：
2017-07
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
Baralle FE;Giudice J
通讯作者：
Giudice J
影响因子：
64.8
作者：
Ghandi, Mahmoud;Huang, Franklin W.;Sellers, William R.
通讯作者：
Sellers, William R.
影响因子：
2.7
作者：
Kim, Chang Seong;Kim, In Jin;Kim, Soo Wan
通讯作者：
Kim, Soo Wan
DOI：
10.1126/science.1262110
发表时间：
2015-05-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
GTEx Consortium
通讯作者：
GTEx Consortium
长非编码 RNA BX357664 通过抑制肾细胞癌中的 TGF-β 1/p38/HSP27 信号传导来调节细胞增殖和上皮间质转化
影响因子：
--
作者：
Liu Y;Qian J;Li X;Chen W;Xu A;Zhao K;Hua Y;Huang Z;Zhang J;Liang C;Su S;Li P;Shao P;Li J;Qin C;Wang Z
通讯作者：
Wang Z