The histopathology of labial salivary glands in primary Sjögren's syndrome: focusing on follicular helper T cells in the inflammatory infiltrates.
The histopathology of labial salivary glands in primary Sjögren's syndrome: focusing on follicular helper T cells in the inflammatory infiltrates.
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DOI：
10.1155/2014/631787
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发表时间：
2014
影响因子：
4.6
通讯作者：
Zeher M
中科院分区：
文献类型：
--
作者：
Szabo K;Papp G;Dezso B;Zeher M
Recently, we revealed the importance of follicular helper T cells (TFH) in the pathogenesis of primary Sjögren's syndrome (pSS). In the present study, we focused on the site of the inflammation and determined the composition of lymphocyte infiltration in labial salivary gland (LSG) biopsies with special emphasis on TFH and germinal center B cells. We selected tissue blocks obtained from ten patients at the time of disease onset. Detection of cell specific markers was performed with immunohistochemical and immunofluorescence stainings. We evaluated patients' clinical and laboratory features retrospectively and assessed the relation between disease course and early histopathological findings. LSG biopsies were graded based on the extension and arrangement level of periductal inflammatory cell infiltrates. TFH cell markers (CD84, PD-1, and Bcl-6) occurred predominantly in more organized structures with higher focus scores. The coexpression of CD3 and Bcl-6 markers clearly identified TFH cells close to Bcl-6+ B cells with the typical formation of germinal centers. Systemic features were developed later in the disease course only in patients with highly structured infiltrates and the presence of TFH cells. Our observations suggest that the presence of TFH cells in LSGs at the disease onset may predict a more pronounced clinical course of pSS.
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DOI：
10.1084/jem.20120994
发表时间：
2012-07-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ma CS;Deenick EK;Batten M;Tangye SG
通讯作者：
Tangye SG
影响因子：
12.8
作者：
Guerrier, Thomas;Le Pottier, Laetitia;Youinou, Pierre
通讯作者：
Youinou, Pierre
影响因子：
32.4
作者：
Choi YS;Kageyama R;Eto D;Escobar TC;Johnston RJ;Monticelli L;Lao C;Crotty S
通讯作者：
Crotty S
影响因子：
3.7
作者：
Larsson, Å;Bredberg, A;Sallmyr, A
通讯作者：
Sallmyr, A
影响因子：
4.6
作者：
Maehara T;Moriyama M;Hayashida JN;Tanaka A;Shinozaki S;Kubo Y;Matsumura K;Nakamura S
通讯作者：
Nakamura S