The origins, function, and regulation of T follicular helper cells.
The origins, function, and regulation of T follicular helper cells.
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DOI：
10.1084/jem.20120994
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发表时间：
2012-07-02
期刊：
影响因子：
--
通讯作者：
Tangye SG
中科院分区：
文献类型：
--
作者：
Ma CS;Deenick EK;Batten M;Tangye SG
在多种微生物自然感染后，高亲和力抗体（Abs）的产生在病原体的中和与清除以及宿主随后的存活中起着关键作用。目前大多数可用的疫苗依赖于记忆B细胞和浆细胞诱导长期的保护性体液免疫反应，这凸显了抗体在宿主保护中的重要性。针对大多数抗原（Ags）的抗体反应需要B细胞和CD4 + T辅助细胞之间的相互作用，并且现在人们已经充分认识到，滤泡辅助性T细胞（Tfh）专门为B细胞提供同源帮助，并且是产生T细胞依赖性B细胞反应所必需的。Tfh细胞发育和/或功能的紊乱可表现为免疫病理，如免疫缺陷、自身免疫和恶性肿瘤。揭示Tfh细胞形成和维持的细胞和分子需求将有助于确定可作为治疗以抗体反应不足或过度为特征的免疫疾病的靶点分子。
The generation of high-affinity antibodies (Abs) plays a critical role in the neutralization and clearance of pathogens and subsequent host survival after natural infection with a variety of microorganisms. Most currently available vaccines rely on the induction of long-lived protective humoral immune responses by memory B cells and plasma cells, underscoring the importance of Abs in host protection. Ab responses against most antigens (Ags) require interactions between B cells and CD4+ T helper cells, and it is now well recognized that T follicular helper cells (Tfh) specialize in providing cognate help to B cells and are fundamentally required for the generation of T cell–dependent B cell responses. Perturbations in the development and/or function of Tfh cells can manifest as immunopathologies, such as immunodeficiency, autoimmunity, and malignancy. Unraveling the cellular and molecular requirements underlying Tfh cell formation and maintenance will help to identify molecules that could be targeted for the treatment of immunological diseases that are characterized by insufficient or excessive Ab responses.
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影响因子：
32.4
作者：
Choi YS;Kageyama R;Eto D;Escobar TC;Johnston RJ;Monticelli L;Lao C;Crotty S
通讯作者：
Crotty S
DOI：
10.1084/jem.20081571
发表时间：
2009-01-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
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DOI：
10.1084/jem.20101773
发表时间：
2011-05-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
Brooks DG
影响因子：
64.8
作者：
Crotty, S;Kersh, EN;Ahmed, R
通讯作者：
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影响因子：
32.4
作者：
Deenick EK;Chan A;Ma CS;Gatto D;Schwartzberg PL;Brink R;Tangye SG
通讯作者：
Tangye SG