Mitosis-related gene CENP-U as a potential biomarker in malignancy.
Mitosis-related gene CENP-U as a potential biomarker in malignancy.
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有丝分裂相关基因 CENP-U 作为恶性肿瘤的潜在生物标志物
DOI：
10.21037/atm-21-6516
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发表时间：
2021-12
影响因子：
--
通讯作者：
Yan X
中科院分区：
文献类型：
--
作者：
Shao C;Wang Y;Duan H;Ding P;Zhang Y;Ning J;Han J;Jiang T;Yan X
研究背景着丝粒蛋白U（CENP-U）是着丝粒的一个组成部分，作为Polo样激酶1（PLK 1）的受体，可调控细胞周期。最近的研究已经部分确定了CENP-U在肿瘤进展中的作用，但CENP-U在肿瘤免疫中的潜在机制仍然不清楚。方法我们使用来自癌症基因组图谱（TCGA）、癌细胞系百科全书（CCLE）数据集和基因型-组织表达（GTEx）项目的数据进行泛癌症分析以评估CENP-U在免疫和增殖中的作用。结果CENP-U在33例肿瘤中的表达水平、预后、肿瘤进展、免疫新抗原和免疫检查点等均与临床病理资料相关。使用肿瘤免疫估计资源（TIMER）数据集分析免疫浸润评分。结果全癌分析结果显示CENP-U在正常组织和常见肿瘤组织中差异表达。CENP-U在正常组织和肿瘤组织中的表达也存在差异，除胸腺瘤（THYM）和弥漫性大B细胞淋巴瘤（DLBC）外，CENP-U的高表达与33种肿瘤的预后不良相关。此外，CENP-U表达与免疫检查点和免疫新抗原之间的相关性被确定。此外，CENP-U表达与肿瘤浸润免疫细胞相关，特别是在THYM中，但在肺鳞状细胞癌（LUSC）、食管癌（ESCA）或肺腺癌（LUAD）中不相关。最后，基因集富集分析（GSEA）表明CENP-U与肿瘤增殖、免疫和代谢密切相关。结论CENP-U是一种有丝分裂相关激酶，在不同类型的肿瘤中表达差异，在肿瘤进展和免疫中起重要作用。CENP-U具有成为预后标志物的潜力，其靶向可能提供治疗益处。
Background Centromere protein U (CENP-U) is a component of the kinetochore and can regulate the cell cycle as a receptor of polo-like kinase 1 (PLK1). Recent studies have partially identified the role of CENP-U in tumor progression, but the underlying mechanisms of CENP-U in tumor immunity remain obscure. Methods We performed pan-cancer analysis to evaluate the role of CENP-U in immunity and proliferation with data from The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE) datasets, and Genotype-Tissue Expression (GTEx) project. Results of CENP-U expression and related clinicopathological data were obtained to show the expression levels, prognosis, tumor progression, immune neoantigens, and immune checkpoints of CENP-U in 33 tumors. The Tumor Immune Estimation Resource (TIMER) dataset was used to analyze immune infiltration scores. Results Results of the pan-cancer analysis demonstrated that CENP-U is differentially expressed in normal tissues and common tumor tissues. Moreover, differentially expressed CENP-U was also identified between matched normal and tumor tissues, and the high expression level of CENP-U was associated with poor prognosis for 33 kinds of tumor except for that of thymoma (THYM) and lymphoid neoplasm diffuse large B-cell lymphoma (DLBC). Furthermore, the correlation between CENP-U expression and immune checkpoints and immune neoantigens was determined. In addition, CENP-U expression was correlated with tumor-infiltrating immune cells especially in THYM but not in lung squamous cell carcinoma (LUSC), esophageal carcinoma (ESCA), or lung adenocarcinoma (LUAD). Finally, gene set enrichment analysis (GSEA) indicated that CENP-U is critically involved in tumor proliferation, immunity, and metabolism. Conclusions CENP-U, a mitosis-related kinase, was found to be differentially expressed across different cancer types and to play an important role in tumor progression and immunity. CENP-U holds the potential to be a prognostic marker, whose targeting may provide therapeutic benefit.
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作者：
Cui Z;Xiao L;Chen F;Wang J;Lin H;Li D;Wu Z
通讯作者：
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影响因子：
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作者：
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影响因子：
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作者：
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影响因子：
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影响因子：
64.8
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Garraway, Levi A.