ELIMINATION OF GRAFT-VERSUS-HOST DISEASE BY IN-VITRO DEPLETION OF ALLOREACTIVE LYMPHOCYTES WITH A MONOCLONAL RAT ANTI-HUMAN LYMPHOCYTE ANTIBODY (CAMPATH-1)
ELIMINATION OF GRAFT-VERSUS-HOST DISEASE BY IN-VITRO DEPLETION OF ALLOREACTIVE LYMPHOCYTES WITH A MONOCLONAL RAT ANTI-HUMAN LYMPHOCYTE ANTIBODY (CAMPATH-1)
复制标题
通过使用单克隆大鼠抗人淋巴细胞抗体 (CAMPATH-1) 体外消除同种异体反应性淋巴细胞来消除移植物抗宿主病
DOI：
10.1016/s0140-6736(84)92564-9
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Shimon Slavin
中科院分区：
文献类型：
--
作者：
H. Waldmann;Geoff Hale;G. Cividalli;Z. Weshler;D. Manor;E. Rachmilewitz;A. Polliak;Reuven Or;Lola Weiss;S. Samuel;C. Brautbar;Shimon Slavin
一种新型单克隆大鼠抗人淋巴细胞抗体 (CAMPATH-1) 可裂解具有自体人补体的细胞，用于在 11 名高危患者移植前体外去除人骨髓同种异体移植物中的 T 淋巴细胞。 HLA 匹配的兄弟姐妹被用作骨髓捐赠者。通过 E-玫瑰花结形成（0-0·18% 残留 T 细胞）和单克隆抗 T 细胞抗体免疫荧光（0-0·5%）测量，T 细胞被大量消耗。移植后未给予抗移植物抗宿主病预防。据报道，所有患者均快速植入，并且移植后过程平安无事。观察最长 12 个月的时间，所有患者均未出现移植物抗宿主病的迹象。该方法可能适用于高危患者的更大规模研究。 2 名患者的晚期移植失败可能反映了 GvHD 未削弱的残余宿主抵抗力。
A new monoclonal rat anti-human lymphocyte antibody (CAMPATH-1) which lyses cells with autologous human complement was used for depletion of T lymphocytes from human bonemarrow allografts in vitro before transplantation in 11 high-risk patients. HLA-matched siblings were used as marrow donors. T-cell depletion was substantial when measured by E-rosette formation (0-0·18% residual T cells) and immunofluorescence with a monoclonal anti-T-cell antibody (0-0·5%). No anti-graft-versus-host disease prophylaxis was given after transplantation. Rapid engraftment was reported in all patients, and the post-transplantation course was uneventful. No signs of graft-versus-host disease developed in any of the patients, who were observed for a maximum period of 12 months. The method might be suitable for larger-scale studies in high-risk patients. The late graft failure seen in 2 patients may reflect residual host resistance uncompromised by GvHD.
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跨越小鼠主要组织相容性障碍的骨髓移植。
影响因子：
6.2
作者：
Vallera,DA;Soderling,CC;Carlson,GJ;Kersey,JH
通讯作者：
Kersey,JH
影响因子：
158.5
作者：
RAMSAY, NKC;KERSEY, JH;NESBIT, ME
通讯作者：
NESBIT, ME
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影响因子：
20.3
作者：
Reisner,Y;Kapoor,N;Kirkpatrick,D;Pollack,MS;Cunningham-Rundles,S;Dupont,B;Hodes,MZ;Good,RA;O'Reilly,RJ
通讯作者：
O'Reilly,RJ
跨越小鼠主要组织相容性障碍的骨髓移植。
DOI：
10.1016/0090-1229(82)90128-3
发表时间：
1982
期刊：
Clinical immunology and immunopathology
影响因子：
--
作者：
Vallera,DA;Filipovich,A;Soderling,CC;Kersey,JH
通讯作者：
Kersey,JH