The impact of Rhodiola rosea on biomarkers of diabetes, inflammation, and microbiota in a leptin receptor-knockout mouse model.
The impact of Rhodiola rosea on biomarkers of diabetes, inflammation, and microbiota in a leptin receptor-knockout mouse model.
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DOI：
10.1038/s41598-022-14241-7
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发表时间：
2022-06-22
影响因子：
4.6
通讯作者：
Van Etten RA
中科院分区：
文献类型：
--
作者：
Jafari M;Juanson Arabit JG;Courville R;Kiani D;Chaston JM;Nguyen CD;Jena N;Liu ZY;Tata P;Van Etten RA
2型糖尿病是世界上最常见的内分泌疾病，近年来肠道微生物区系已成为其治疗的潜在靶点。最近的研究表明，这种疾病可能使个人倾向于某些微生物组组成，而二甲双胍等治疗已被证明改变肠道微生物区系及其相关的代谢途径。然而，考虑到目前用于治疗糖尿病的药物的局限性和副作用，有必要进行替代治疗。在这项研究中，我们研究了红景天根提取物对瘦素受体基因敲除(db/db)的2型糖尿病小鼠模型的影响。我们之前的工作表明，红景天具有抗炎和肠道微生物群调节特性，同时在几种动物模型中延长寿命。在这项研究中，红景天的治疗改善了空腹血糖水平，改变了对外源性胰岛素的反应，并降低了循环脂多糖和肝脏C反应蛋白转录水平。我们推测，这些变化可能在一定程度上反映了微生物区系的调节，导致肠道屏障完整性的改善，并减少了炎性生物分子向血流的移位。这些发现表明，红景天是一种有吸引力的治疗2型糖尿病的进一步研究的候选药物。
Type 2 diabetes is the most prevalent endocrine disease in the world, and recently the gut microbiota have become a potential target for its management. Recent studies have illustrated that this disease may predispose individuals to certain microbiome compositions, and treatments like metformin have been shown to change gut microbiota and their associated metabolic pathways. However, given the limitations and side effects associated with pharmaceuticals currently being used for therapy of diabetes, there is a significant need for alternative treatments. In this study, we investigated the effects of a root extract from Rhodiola rosea in a Leptin receptor knockout (db/db) mouse model of type 2 diabetes. Our previous work showed that Rhodiola rosea had anti-inflammatory and gut microbiome-modulating properties, while extending lifespan in several animal models. In this study, treatment with Rhodiola rosea improved fasting blood glucose levels, altered the response to exogenous insulin, and decreased circulating lipopolysaccharide and hepatic C-reactive protein transcript levels. We hypothesize that these changes may in part reflect the modulation of the microbiota, resulting in improved gut barrier integrity and decreasing the translocation of inflammatory biomolecules into the bloodstream. These findings indicate that Rhodiola rosea is an attractive candidate for further research in the management of type 2 diabetes.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
糖尿病的医疗标准 - 2010年。
影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
48
作者：
Callahan BJ;McMurdie PJ;Rosen MJ;Han AW;Johnson AJ;Holmes SP
通讯作者：
Holmes SP
影响因子：
24.5
作者：
Cani PD;Possemiers S;Van de Wiele T;Guiot Y;Everard A;Rottier O;Geurts L;Naslain D;Neyrinck A;Lambert DM;Muccioli GG;Delzenne NM
通讯作者：
Delzenne NM
影响因子：
5.2
作者：
Geurts L;Lazarevic V;Derrien M;Everard A;Van Roye M;Knauf C;Valet P;Girard M;Muccioli GG;François P;de Vos WM;Schrenzel J;Delzenne NM;Cani PD
通讯作者：
Cani PD