Peripheral Neutrophil to Lymphocyte Ratio Improves Prognostication in Colon Cancer.
Peripheral Neutrophil to Lymphocyte Ratio Improves Prognostication in Colon Cancer.
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DOI：
10.1016/j.clcc.2017.01.008
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发表时间：
2017-06
影响因子：
3.4
通讯作者：
Boardman LA
中科院分区：
文献类型：
--
作者：
Rashtak S;Ruan X;Druliner BR;Liu H;Therneau T;Mouchli M;Boardman LA
我们研究了外周中性粒细胞与淋巴细胞比率（NLR）对结肠癌和直肠癌生存结果的作用，以确定在现有分期系统中纳入NLR是否能改善预后。计算2536例I-III期结肠癌或直肠癌患者的无病生存期和总生存期（DFS和OS）预处理NLR的风险比（HR），并根据年龄、阳性/总淋巴结数、T分期和分级进行调整。评估NLR与临床病理特征和生存的关系，并与美国癌症联合委员会（AJCC） TNM分期和纪念斯隆凯特林癌症中心（MSKCC）模型进行比较。高NLR与各阶段结肠癌患者较差的DFS （HR: 1.36 [95%CI 1.08-1.70] p: 0.009）和OS （HR: 1.65 [95%CI 1.29-2.10] p<0.0005）显著相关，但与直肠癌患者无关。高NLR与部位特异性较差的预后显著相关，左结肠比右结肠的预后更差；与品位成反比关系。高NLR对DFS和OS的影响发生较早，大多数死亡发生在手术后2年内。结肠癌患者NLR每增加2个单位，5年和2年预后的调整hr分别为1.15 （95% CI 1.08-1.23）和1.20 （95% CI 1.10-1.30）。NLR的加入增强了TNM的预后效用(单独TNM vs. TNM + NLR: c指数0。60 vs. 0.68)和MSKCC （MSKCC单独vs. MSKCC + NLR: c指数0.71 vs. 0.73）结肠癌患者模型。NLR是非转移性结肠癌的独立预后变量，增强了现有的临床分期系统。
We studied the role of peripheral Neutrophil to Lymphocyte Ratio (NLR) on survival outcomes in colon and rectal cancer to determine if its inclusion improved prognostication within existing staging systems. Disease free and overall survival (DFS and OS) Hazard Ratios (HR) of pretreatment NLR were calculated for 2536 stage I-III colon or rectal cancer patients and adjusted for age, positive/total number of nodes, T stage, and grade. The association of NLR with clinicopathologic features and survival was evaluated and compared to American Joint Committee on cancer (AJCC) TNM staging and Memorial Sloan Kettering Cancer Center (MSKCC) models. High NLR was significantly associated with worse DFS (HR: 1.36 [95% CI 1.08–1.70] p: 0.009) and OS (HR: 1.65 [95%CI 1.29–2.10] p<0.0005) in all stages for colon, but not rectal cancer patients. High NLR was significantly associated with site-specific worse prognosis which was stronger in the left vs right colon; an inverse relationship with grade was found. The impact of high NLR on DFS and OS occurred early with the majority of deaths within 2 years following surgery. Adjusted HRs for 5-year and 2-year outcomes in colon cancer per each additional 2-unit increase in NLR were 1.15 (95% CI 1.08–1.23) and 1.20 (95% CI 1.10–1.30), respectively. Addition of NLR enhanced prognostic utility of TNM (TNM alone vs. TNM + NLR: C-index 0. 60 vs. 0.68), and MSKCC (MSKCC alone vs MSKCC + NLR: C-index 0.71 vs. 0.73) models for colon cancer patients. NLR is an independent prognostic variable for non-metastatic colon cancer that enhances existing clinical staging systems.
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影响因子：
8.8
作者：
Schmidt, H;Bastholt, L;Geertsen, P;Christensen, I;Larsen, S;Gehl, J;von der Maase, H
通讯作者：
von der Maase, H
影响因子：
7.4
作者：
Galon J;Pagès F;Marincola FM;Angell HK;Thurin M;Lugli A;Zlobec I;Berger A;Bifulco C;Botti G;Tatangelo F;Britten CM;Kreiter S;Chouchane L;Delrio P;Arndt H;Asslaber M;Maio M;Masucci GV;Mihm M;Vidal-Vanaclocha F;Allison JP;Gnjatic S;Hakansson L;Huber C;Singh-Jasuja H;Ottensmeier C;Zwierzina H;Laghi L;Grizzi F;Ohashi PS;Shaw PA;Clarke BA;Wouters BG;Kawakami Y;Hazama S;Okuno K;Wang E;O'Donnell-Tormey J;Lagorce C;Pawelec G;Nishimura MI;Hawkins R;Lapointe R;Lundqvist A;Khleif SN;Ogino S;Gibbs P;Waring P;Sato N;Torigoe T;Itoh K;Patel PS;Shukla SN;Palmqvist R;Nagtegaal ID;Wang Y;D'Arrigo C;Kopetz S;Sinicrope FA;Trinchieri G;Gajewski TF;Ascierto PA;Fox BA
通讯作者：
Fox BA
影响因子：
50.5
作者：
Klingbiel, D.;Saridaki, Z.;Tejpar, S.
通讯作者：
Tejpar, S.
DOI：
10.1093/annonc/mds614
发表时间：
2013-05
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Merok MA;Ahlquist T;Røyrvik EC;Tufteland KF;Hektoen M;Sjo OH;Mala T;Svindland A;Lothe RA;Nesbakken A
通讯作者：
Nesbakken A
影响因子：
3.7
作者：
Tohme, Samer;Sukato, Daniel;Tsung, Allan
通讯作者：
Tsung, Allan