Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series.
Microsatellite instability has a positive prognostic impact on stage II colorectal cancer after complete resection: results from a large, consecutive Norwegian series.
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DOI：
10.1093/annonc/mds614
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Nesbakken A
中科院分区：
文献类型：
--
作者：
Merok MA;Ahlquist T;Røyrvik EC;Tufteland KF;Hektoen M;Sjo OH;Mala T;Svindland A;Lothe RA;Nesbakken A
微卫星不稳定性(MSI)在1993年被认为是结直肠癌预后良好的标志，2005年的系统回顾和2010年的荟萃分析支持了最初的观察结果。我们在挪威奥斯陆的一家医院，通过一系列连续的、基于人群的研究，评估了不同阶段MSI的预后影响和患病率。在1274名患者中，952人接受了大部切除术，其中805人被纳入MSI患病率分析，613人在预后分析中被完全切除。福尔马林固定的肿瘤组织用于基于聚合酶链式反应的MSI分析。MSI的总体患病率为14%，女性(19%)和近端结肠癌(29%)的患病率最高。在多因素分析中，微囊癌和多发性硬化瘤患者的5年无复发生存率分别为67%和55%(P=0.030)，危险比(HR)=1.6(P=0.045)。改善的结果仅限于II期患者，5年RFS分别为74%和56%(P=0.010)，HR=2.02(P=0.040)。检查12个或更多的淋巴结与肿瘤的近端位置显著相关(P<；0.001)。MSI对完全切除后II期结直肠癌患者的预后有独立的积极影响。
Microsatellite instability (MSI) was suggested as a marker for good prognosis in colorectal cancer in 1993 and a systematic review from 2005 and a meta-analysis from 2010 support the initial observation. We here assess the prognostic impact and prevalence of MSI in different stages in a consecutive, population-based series from a single hospital in Oslo, Norway. Of 1274 patients, 952 underwent major resection of which 805 were included in analyses of MSI prevalence and 613 with complete resection in analyses of outcome. Formalin-fixed tumor tissue was used for PCR-based MSI analyses. The overall prevalence of MSI was 14%, highest in females (19%) and in proximal colon cancer (29%). Five-year relapse-free survival (5-year RFS) was 67% and 55% (P = 0.030) in patients with MSI and MSS tumors, respectively, with the hazard ratio (HR) equal to 1.60 (P = 0.045) in multivariate analysis. The improved outcome was confined to stage II patients who had 5-year RFS of 74% and 56% respectively (P = 0.010), HR = 2.02 (P = 0.040). Examination of 12 or more lymph nodes was significantly associated with proximal tumor location (P < 0.001). MSI has an independent positive prognostic impact on stage II colorectal cancer patients after complete resection.
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影响因子：
64.8
作者：
BRONNER, CE;BAKER, SM;LISKAY, RM
通讯作者：
LISKAY, RM
影响因子：
24.5
作者：
Jass, JR;Do, KA;Leggett, B
通讯作者：
Leggett, B
影响因子：
45.3
作者：
Lanza, Giovanni;Gafa, Roberta;Cavazzini, Luigi
通讯作者：
Cavazzini, Luigi
影响因子：
9.6
作者：
CHAPUIS, PH;DENT, OF;COLQUHOUN, K
通讯作者：
COLQUHOUN, K
影响因子：
3.7
作者：
Belt EJ;te Velde EA;Krijgsman O;Brosens RP;Tijssen M;van Essen HF;Stockmann HB;Bril H;Carvalho B;Ylstra B;Bonjer HJ;Meijer GA
通讯作者：
Meijer GA