Zika virus infection of first-trimester human placentas: utility of an explant model of replication to evaluate correlates of immune protection ex vivo.
Zika virus infection of first-trimester human placentas: utility of an explant model of replication to evaluate correlates of immune protection ex vivo.
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DOI：
10.1016/j.coviro.2017.11.008
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发表时间：
2017-12
影响因子：
5.9
通讯作者：
Pereira L
中科院分区：
文献类型：
--
作者：
Petitt M;Tabata T;Puerta-Guardo H;Harris E;Pereira L
先天性寨卡病毒（ZIKV）疾病的出现对胎儿具有毁灭性影响，促使人们开发疫苗，并研究寨卡病毒如何突破母胎屏障。胎盘和蜕膜组织外植体的感染表明子宫-胎盘界面的细胞类型易受感染，并提示通过胎盘和羊膜的传播途径。寨卡病毒在严重先天性感染的胎盘绒毛膜绒毛内增殖的霍夫鲍尔细胞中复制。锚定绒毛的外植体再现了胎盘的结构和早期发育，表明受感染的霍夫鲍尔细胞将病毒传播到胎儿血管。寨卡病毒外植体感染是评估疫苗接受者、被动免疫制剂和新疗法中抗体对传播的保护作用的替代人类模型。
The emergence of congenital Zika virus (ZIKV) disease, with its devastating effects on the fetus, has prompted development of vaccines and examination of how ZIKV breaches the maternal-fetal barrier. Infection of placental and decidual tissue explants has demonstrated cell types at the uterine-placental interface susceptible to infection and suggests routes for transmission across the placenta and amniochorionic membrane. ZIKV replicates in proliferating Hofbauer cells within chorionic villi in placentas from severe congenital infection. Explants of anchoring villi recapitulate placental architecture and early-stage development and suggest infected Hofbauer cells disseminate virus to fetal blood vessels. ZIKV infection of explants represents a surrogate human model for evaluating protection against transmission by antibodies in vaccine recipients and passive immune formulations and novel therapeutics.
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DOI：
10.1056/nejmoa1602412
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brasil P;Pereira JP Jr;Moreira ME;Ribeiro Nogueira RM;Damasceno L;Wakimoto M;Rabello RS;Valderramos SG;Halai UA;Salles TS;Zin AA;Horovitz D;Daltro P;Boechat M;Raja Gabaglia C;Carvalho de Sequeira P;Pilotto JH;Medialdea-Carrera R;Cotrim da Cunha D;Abreu de Carvalho LM;Pone M;Machado Siqueira A;Calvet GA;Rodrigues Baião AE;Neves ES;Nassar de Carvalho PR;Hasue RH;Marschik PB;Einspieler C;Janzen C;Cherry JD;Bispo de Filippis AM;Nielsen-Saines K
通讯作者：
Nielsen-Saines K
影响因子：
168.9
作者：
Franca, Giovanny V. A.;Schuler-Faccini, Lavinia;Victora, Cesar G.
通讯作者：
Victora, Cesar G.
影响因子：
30.3
作者：
Beltramello M;Williams KL;Simmons CP;Macagno A;Simonelli L;Quyen NT;Sukupolvi-Petty S;Navarro-Sanchez E;Young PR;de Silva AM;Rey FA;Varani L;Whitehead SS;Diamond MS;Harris E;Lanzavecchia A;Sallusto F
通讯作者：
Sallusto F
影响因子：
17.1
作者：
Beatty, P. Robert;Puerta-Guardo, Henry;Harris, Eva
通讯作者：
Harris, Eva
影响因子：
158.5
作者：
Driggers, R. W.;Ho, C. -Y.;Vapalahti, O.
通讯作者：
Vapalahti, O.