Distribution of vesicular glutamate transporter 2 (VGluT2) in the primary visual cortex of the macaque and human.
Distribution of vesicular glutamate transporter 2 (VGluT2) in the primary visual cortex of the macaque and human.
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DOI：
10.1002/cne.23165
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发表时间：
2013-01-01
影响因子：
2.5
通讯作者：
Hawken, Michael J.
中科院分区：
文献类型：
--
作者：
Garcia-Marin, Virginia;Ahmed, Tunazzina H.;Afzal, Yasmeen C.;Hawken, Michael J.
V1的大部分丘脑末梢来自外侧膝状核（LGN）传入。丘脑传入末端优先被谷氨酸囊泡转运蛋白VGluT2的异构体标记。我们的研究目的是确定VGluT2-ir点在猕猴和人类视觉皮层的分布。首先，我们研究了VGluT2-ir点在猕猴初级视觉皮层（V1）各层的分布，发现以往研究中已知的LGN事件分布与vglut2免疫反应性（-ir）点的分布非常接近。细胞色素氧化酶密度与VGluT2-ir点分布密切相关。在验证了猕猴的对应关系后，我们对人类V1进行了比较研究。在许多方面，VGluT2-ir点在人体内的分布与猕猴在质上相似：4C层密度高，谷粒上层有斑块分布（2/3），1层和6层分布较低但很清晰，5层和4B层很少。然而，猕猴和人类之间也存在着重要的差异。在人类的4A层中，VGluT2-ir点分布稀疏，而在猕猴中，VGluT2-ir点分布密集，具有典型的蜂窝状组织。结果表明，皮层VGluT2免疫染色模式的重要变化可能与旧大陆猴和人类LGN传入事件皮层组织的进化差异有关。
The majority of thalamic terminals in V1 arise from lateral geniculate nucleus (LGN) afferents. Thalamic afferent terminals are preferentially labeled by an isoform of the vesicular glutamate transporter, VGluT2. The goal of our study was to determine the distribution of VGluT2-ir puncta in macaque and human visual cortex. First, we investigated the distribution of VGluT2-ir puncta in all layers of macaque monkey primary visual cortex (V1), and found a very close correspondence between the known distribution of LGN afferents from previous studies and the distribution of VGluT2-immunoreactive (-ir) puncta. There was also a close correspondence between cytochrome oxidase density and VGluT2-ir puncta distribution. After validating the correspondence in macaque, we made a comparative study in human V1. In many aspects, the distribution of VGluT2-ir puncta in human was qualitatively similar to that of the macaque: high densities in layer 4C, patches of VGluT2-ir puncta in the supragranular layer (2/3), lower but clear distribution in layers 1 and 6, and very few puncta in layers 5 and 4B. However, there were also important differences between macaques and humans. In layer 4A of human, there was a sparse distribution of VGluT2-ir puncta, whereas in macaque, there was a dense distribution with the characteristic honeycomb organization. The results suggest important changes in the pattern of cortical VGluT2 immunostaining that may be related to evolutionary differences in the cortical organization of LGN afferents between Old World monkeys and humans.
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丘脑皮质突触的快速结构重塑使小鼠初级视觉皮层的经验依赖性功能可塑性。
DOI：
10.1523/jneurosci.1248-10.2010
发表时间：
2010-07-21
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Coleman JE;Nahmani M;Gavornik JP;Haslinger R;Heynen AJ;Erisir A;Bear MF
通讯作者：
Bear MF
影响因子：
3.7
作者：
Casagrande, V. A.;Yazar, F.;Ding, Y.
通讯作者：
Ding, Y.
影响因子：
2.5
作者：
Boulland, JL;Qureshi, T;Chaudhry, FA
通讯作者：
Chaudhry, FA
影响因子：
64.8
作者：
Más, P;Kim, WY;Kay, SA
通讯作者：
Kay, SA
影响因子：
2.5
作者：
Baldwin, Mary K. L.;Kaskan, Peter M.;Zhang, Bin;Chino, Yuzo M.;Kaas, Jon H.
通讯作者：
Kaas, Jon H.