Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum.
Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum.
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DOI：
10.1038/ncomms5446
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发表时间：
2014-07-25
影响因子：
16.6
通讯作者：
Cerami C
中科院分区：
文献类型：
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作者：
Clark MA;Goheen MM;Fulford A;Prentice AM;Elnagheeb MA;Patel J;Fisher N;Taylor SM;Kasthuri RS;Cerami C
缺铁和疟疾在全球分布相似，并且经常在孕妇和幼儿中共存。在这两种情况普遍存在的地方，补铁变得复杂，因为观察到缺铁性贫血可以预防恶性疟疾，而且补铁增加了对临床意义重大的疟疾的易感性，但其机制仍然不清楚。在这里，使用体外寄生虫培养系统，从缺铁和充实的人供体红细胞，我们证明恶性疟原虫感染缺乏铁的红细胞效率较低。此外，由于merozoite偏爱年轻红细胞，缺铁个体补充铁可以逆转缺铁的保护作用。我们的研究结果为实地观察报告的铁缺乏对人疟疾易感性的保护作用和铁给药的有害影响提供了实验验证。由于贫血的恢复需要短暂的网状细胞缺乏症，我们的研究结果表明，在疟疾流行地区，补充铁应该伴随着有效的预防恶性疟疾的措施。
Iron deficiency and malaria have similar global distributions, and frequently co-exist in pregnant women and young children. Where both conditions are prevalent, iron supplementation is complicated by observations that iron deficiency anaemia protects against falciparum malaria, and that iron supplements increase susceptibility to clinically significant malaria, but the mechanisms remain obscure. Here, using an in vitro parasite culture system with erythrocytes from iron-deficient and replete human donors, we demonstrate that Plasmodium falciparum infects iron-deficient erythrocytes less efficiently. In addition, owing to merozoite preference for young erythrocytes, iron supplementation of iron-deficient individuals reverses the protective effects of iron deficiency. Our results provide experimental validation of field observations reporting protective effects of iron deficiency and harmful effects of iron administration on human malaria susceptibility. Because recovery from anaemia requires transient reticulocytosis, our findings imply that in malarious regions iron supplementation should be accompanied by effective measures to prevent falciparum malaria.
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影响因子：
12.8
作者：
Bei, Amy K.;DeSimone, Tiffany M.;Badiane, Aida S.;Ahouidi, Ambroise D.;Dieye, Tandakha;Ndiaye, Daouda;Sarr, Ousmane;Ndir, Omar;Mboup, Souleymane;Duraisingh, Manoj T.
通讯作者：
Duraisingh, Manoj T.
影响因子：
3.7
作者：
Sangare, Laura;van Eijk, Anna Maria;Stergachis, Andy
通讯作者：
Stergachis, Andy
影响因子：
6.4
作者：
Nyakeriga, AM;Troye-Blomberg, M;Williams, TN
通讯作者：
Williams, TN
影响因子：
9.3
作者：
Church J;Maitland K
通讯作者：
Maitland K
影响因子：
82.9
作者：
通讯作者：
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