The long-term effects of a polygenetic predisposition to general cognition on healthy cognitive ageing: evidence from the English Longitudinal Study of Ageing.
The long-term effects of a polygenetic predisposition to general cognition on healthy cognitive ageing: evidence from the English Longitudinal Study of Ageing.
复制标题
DOI：
10.1017/s0033291721004827
复制
发表时间：
2023-05
影响因子：
6.9
通讯作者：
Cadar, Dorina
中科院分区：
文献类型：
--
作者：
Ajnakina, Olesya;Murray, Robin;Steptoe, Andrew;Cadar, Dorina
由于认知能力的加速下降往往预示着严重的神经病理疾病的发生，了解个体在抵御认知老化冲击方面存在差异的根源，可能会突显如何将最佳认知能力保留到老年。本研究以英国老龄化纵向研究的5088名50岁成年人为样本，研究了多基因易感与一般认知之间的关系及其与10年内认知变化率的关系。用一般认知多基因评分(GC-PGS)测量多基因易感性。通过言语记忆和语义流畅性测试来衡量认知能力。平均基线记忆得分为11.1(S.D.=2.9)，执行功能评分为21.5(S.D.=5.8)。GC-PGS增加一个标准差(1-S.D.)与更高的基线语言记忆相关的平均0.27点(95%可信区间为0.19-0.34，p<；0.001)。类似地，1-S.D.在整个样本中，GC-PG的增加与基线时较高的语义流畅性得分相关(β=0.45，95%CI为0.27-0.64，p<；0.001)。这些关联对女性和男性以及所有年龄段的人都很重要。尽管如此，1-S.D.在整个样本的随访中，GC-PGS的增加与言语记忆或语义流畅性的下降无关，也与按性别和年龄分层的模型无关。虽然与一般认知相关的常见遗传变异与成年人的认知盈余稳定相关，但在10年的随访中，一般认知的多基因倾向与年龄相关的认知下降无关。
As an accelerated cognitive decline frequently heralds onset of severe neuropathological disorders, understanding the source of individual differences in withstanding the onslaught of cognitive ageing may highlight how best cognitive abilities may be retained into advanced age. Using a population representative sample of 5088 adults aged •50 years from the English Longitudinal Study of Ageing, we investigated relationships of polygenic predisposition to general cognition with a rate of change in cognition during a 10-year follow-up period. Polygenic predisposition was measured with polygenic scores for general cognition (GC-PGS). Cognition was measured employing tests for verbal memory and semantic fluency. The average baseline memory score was 11.1 (s.d. = 2.9) and executive function score was 21.5 (s.d. = 5.8). An increase in GC-PGS by one standard deviation (1-s.d.) was associated with a higher baseline verbal memory by an average 0.27 points (95% CI 0.19–0.34, p < 0.001). Similarly, 1-s.d. increase in GC-PGS was associated with a higher semantic fluency score at baseline in the entire sample (β = 0.45, 95% CI 0.27–0.64, p < 0.001). These associations were significant for women and men, and all age groups. Nonetheless, 1-s.d. increase in GC-PGS was not associated with decreases in verbal memory nor semantic fluency during follow-up in the entire sample, as well stratified models by sex and age. Although common genetic variants associated with general cognition additively are associated with a stable surplus to cognition in adults, a polygenic predisposition to general cognition is not associated with age-related cognitive decline during a 10-year follow-up.
影响因子：
4
作者：
Finkel, Deborah;Reynolds, Chandra A.;McArdle, John J.;Hamagami, Fumiaki;Pedersen, Nancy L.
通讯作者：
Pedersen, Nancy L.