Genetic variance in processing speed drives variation in aging of spatial and memory abilities.
Genetic variance in processing speed drives variation in aging of spatial and memory abilities.
复制标题
DOI：
10.1037/a0015332
复制
发表时间：
2009-05
影响因子：
4
通讯作者：
Pedersen, Nancy L.
中科院分区：
文献类型：
--
作者：
Finkel, Deborah;Reynolds, Chandra A.;McArdle, John J.;Hamagami, Fumiaki;Pedersen, Nancy L.
关键词：
先前的分析已经确定了基因对处理速度随年龄下降和更高的认知能力之间的相关性的贡献。当前分析的目标是应用生物计量双变化分数模型来考虑处理速度和认知能力的老化轨迹之间的遗传协方差的时间动态的可能性。纵向双胞胎数据从瑞典采用/双胞胎老化研究，包括多达5个测量场合，涵盖了16年的时间，可从806名参与者的年龄范围从50至88岁的第一次测量波。因子被生成以挖掘4个认知领域：言语能力、空间能力、记忆和处理速度。模型拟合表明，加工速度的遗传方差是空间和记忆能力年龄变化的主要指标，为认知老化的加工速度理论提供了额外的支持。
Previous analyses have identified a genetic contribution to the correlation between declines with age in processing speed and higher cognitive abilities. The goal of the current analysis was to apply the biometric dual change score model to consider the possibility of temporal dynamics underlying the genetic covariance between aging trajectories for processing speed and cognitive abilities. Longitudinal twin data from the Swedish Adoption/Twin Study of Aging, including up to 5 measurement occasions covering a 16-year period, were available from 806 participants ranging in age from 50 to 88 years at the 1st measurement wave. Factors were generated to tap 4 cognitive domains: verbal ability, spatial ability, memory, and processing speed. Model-fitting indicated that genetic variance for processing speed was a leading indicator of variation in age changes for spatial and memory ability, providing additional support for processing speed theories of cognitive aging.
登录
查看更多内容
影响因子：
1.9
作者：
Finkel, D;Pedersen, NL
通讯作者：
Pedersen, NL
影响因子：
3.7
作者：
Finkel, Deborah;McArdle, John J.;Pedersen, Nancy L.
通讯作者：
Pedersen, Nancy L.
DOI：
10.1093/gerona/52a.2.m117
发表时间：
1997-03-01
影响因子：
5.1
作者：
Gatz, M;Pedersen, NL;Ahlbom, A
通讯作者：
Ahlbom, A
影响因子：
3.7
作者：
HULTSCH, DF;HERTZOG, C;DIXON, RA
通讯作者：
DIXON, RA
影响因子：
3.7
作者：
Lövdén, M;Ghisletta, P;Lindenberger, U
通讯作者：
Lindenberger, U