Spread of Cryptococcus gattii into Pacific Northwest region of the United States.
Spread of Cryptococcus gattii into Pacific Northwest region of the United States.
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DOI：
10.3201/eid1508.081384
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发表时间：
2009-08
影响因子：
11.8
通讯作者：
Cryptococcus gattii Working Group of the Pacific Northwest
中科院分区：
文献类型：
--
作者：
Datta K;Bartlett KH;Baer R;Byrnes E;Galanis E;Heitman J;Hoang L;Leslie MJ;MacDougall L;Magill SS;Morshed MG;Marr KA;Cryptococcus gattii Working Group of the Pacific Northwest
这种微生物应该被认为是美国的一种新的病原体。加蒂隐球菌现已成为太平洋西北部的一种人和动物病原体。它最初在加拿大不列颠哥伦比亚省温哥华岛被发现，现在涉及不列颠哥伦比亚省大陆，以及美国的华盛顿州和俄勒冈州。在加拿大，疾病的发病率一直是世界上最高的之一。在美国，缺乏隐球菌种鉴定和病例监测限制了我们对加蒂卡氏菌流行病学的了解。太平洋西北部的感染是由多种基因类型引起的，但主要的毒株在基因上是新的，可能是最近出现的，与独特的交配或环境变化有关。加蒂亚氏菌病影响免疫受损和免疫能力低下的人，导致重大疾病和死亡。成功的治疗需要积极的内科和外科方法，并考虑到潜在的不同的抗真菌药物敏感性。我们总结了一组调查人员的研究结果，并审查了目前的知识，目的是提高认识，并强调需要进一步知识的领域。
This organism should be recognized as an emerging pathogen in the United States. Cryptococcus gattii has emerged as a human and animal pathogen in the Pacific Northwest. First recognized on Vancouver Island, British Columbia, Canada, it now involves mainland British Columbia, and Washington and Oregon in the United States. In Canada, the incidence of disease has been one of the highest worldwide. In the United States, lack of cryptococcal species identification and case surveillance limit our knowledge of C. gattii epidemiology. Infections in the Pacific Northwest are caused by multiple genotypes, but the major strain is genetically novel and may have emerged recently in association with unique mating or environmental changes. C. gattii disease affects immunocompromised and immunocompetent persons, causing substantial illness and death. Successful management requires an aggressive medical and surgical approach and consideration of potentially variable antifungal drug susceptibilities. We summarize the study results of a group of investigators and review current knowledge with the goal of increasing awareness and highlighting areas where further knowledge is required.
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影响因子：
5.2
作者：
Khan, Zia U.;Randhawa, Harbans S.;Chandy, Rachel
通讯作者：
Chandy, Rachel
DOI：
10.1155/2007/319296
发表时间：
2007-05-01
影响因子：
2.8
作者：
Levy, Ron;Pitout, Johann;Gill, M. John
通讯作者：
Gill, M. John
影响因子：
11.8
作者：
Chaturvedi S;Dyavaiah M;Larsen RA;Chaturvedi V
通讯作者：
Chaturvedi V
影响因子：
1.9
作者：
Bovers, Marjan;Hagen, Ferry;Boekhout, Teun
通讯作者：
Boekhout, Teun
影响因子：
--
作者：
Campbell, LT;Currie, BJ;Carter, D
通讯作者：
Carter, D