Total IgE levels and asthma prevalence in the US population: results from the National Health and Nutrition Examination Survey 2005-2006.
Total IgE levels and asthma prevalence in the US population: results from the National Health and Nutrition Examination Survey 2005-2006.
复制标题
DOI：
10.1016/j.jaci.2009.06.011
复制
发表时间：
2009-09
影响因子：
14.2
通讯作者：
Zeldin, Darryl C.
中科院分区：
文献类型：
--
作者：
Gergen, Peter J.;Arbes, Samuel J., Jr.;Calatroni, Agustin;Mitchell, Herman E.;Zeldin, Darryl C.
无法测量基于IgE对所有过敏原的敏感性限制了我们对哮喘中有多少与IgE相关的理解。总IgE有可能克服这一局限。
确定总IgE与哮喘之间的关联
2005 - 2006年美国国家健康与营养检查调查（NHANES）对6岁及以上的美国代表性人群样本进行了检查。
总IgE的中位数为40.8 kU/L（四分位距15.5 - 114）。总IgE水平随年龄、性别、种族/民族、血清可替宁、体型和社会经济状况而变化。当前哮喘的患病率为8.8%。按照15种特异性IgE定义，特应性的患病率为42.5%。总IgE增加10倍时，哮喘的调整后优势比（OR）为2.18（95%置信区间：1.66 - 2.87）。总IgE仅在特应性人群中可预测哮喘，OR = 2.41（95%置信区间：1.62 - 3.60），在非特应性人群中则不然，OR = 1.11（95%置信区间：0.72 - 1.71）（交互作用p = 0.005）。在特应性人群中，随着特异性IgE检测阳性数量的增加，总IgE与哮喘之间的关联变得更强。无论特应性状态如何，即使在总IgE水平极低时也存在哮喘。大约92%的特应性人群可通过6种特异性IgE确定，但要将识别率提高到99%以上则需要11种特异性IgE。
总IgE仅在至少对一种过敏原特异性IgE呈阳性的人群中与哮喘相关。在美国人群中，不依赖IgE的哮喘并不罕见。要完全识别一个人群中的特应性个体，需要大量的过敏原特异性IgE组合。
The inability to measure IgE-based sensitivity to all allergens has limited our understanding of what portion of asthma is related to IgE. Total IgE can potentially overcome this limitation. Determine the association between total IgE and asthma The National Health and Nutrition Examination Survey (NHANES) 2005–2006 examined a representative sample of the U.S. population 6 years of age and older. The median total IgE was 40.8 kU/L (IQR 15.5 – 114). Total IgE levels varied with age, sex, race/ethnicity, serum cotinine, body size, and socioeconomic status. The prevalence of current asthma was 8.8%. The prevalence of atopy was 42.5% as defined by 15 specific IgEs. The adjusted odds ratio (OR) for asthma with a 10-fold increase in total IgE was 2.18 (95% CI: 1.66–2.87). Total IgE predicted asthma only among atopics OR = 2.41 (95% CI: 1.62–3.60) not non-atopics OR = 1.11 (95% CI: 0.72–1.71) (interaction p=0.005). Among atopics, the association between total IgE and asthma became stronger as the number of positive specific IgE tests increased. Asthma was present at even the lowest levels of total IgE, regardless of atopic status. Approximately 92% of atopics were identified by six specific IgEs, but to increase the identification to over 99% required 11 specific IgEs. Total IgE is associated with asthma only among persons who are positive to at least one allergen-specific IgEs. Asthma independent of IgE is not uncommon in the US populations. The complete identification of atopics in a population requires a large panel of allergen-specific IgEs.
登录
查看更多内容
影响因子：
14.2
作者：
Gruchalla, RS;Pongracic, J;Mitchell, H
通讯作者：
Mitchell, H
影响因子：
--
作者：
Boustiere, Ch.;Castellani, P.
通讯作者：
Castellani, P.
影响因子：
14.2
作者：
Arbes, Samuel J., Jr.;Gergen, Peter J.;Zeldin, Darryl C.
通讯作者：
Zeldin, Darryl C.
影响因子：
24.3
作者：
Beeh, KM;Ksoll, M;Buhl, R
通讯作者：
Buhl, R
影响因子：
8
作者：
Arshad, SH;Tariq, SM;Hakim, E
通讯作者：
Hakim, E