Association of pediatric psoriasis severity with excess and central adiposity: an international cross-sectional study.
Association of pediatric psoriasis severity with excess and central adiposity: an international cross-sectional study.
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DOI：
10.1001/jamadermatol.2013.1078
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发表时间：
2013-02
期刊：
影响因子：
10.9
通讯作者：
Seyger, Marieke M. B.
中科院分区：
文献类型：
--
作者：
Paller, Amy S.;Mercy, Katherine;Kwasny, Mary J.;Choon, Siew Eng;Cordoro, Kelly M.;Girolomoni, Giampiero;Menter, Alan;Tom, Wynnis L.;Mahoney, Anne M.;Oostveen, Annet M.;Seyger, Marieke M. B.
探讨过度肥胖和中心性肥胖与儿童银屑病严重程度的关系。409例银屑病患儿的多中心横断面研究。银屑病被分类为轻度（最差医师总体评估（PGA）<3，体表面积（BSA）<10%）或重度（最差PGA >3，BSA >10%）。2009年7月至2011年12月，9个国家的儿童入组。过度肥胖（体重指数（BMI）百分位数）和中心性肥胖（腰围（WC）百分位数和腰围身高比）。过度肥胖（BMI >第85百分位数）发生在37.8%（n=155）的银屑病患者和20.5%（n=42）的对照组中，但在严重程度上没有差异。肥胖的几率银屑病患者与对照组相比，总体（BMI >第95百分位数）OR=4.29，95%CI =1.96-9.39，但重度银屑病患者的OR更高，（OR=4.92，CI=2.20-10.99）比轻度（OR=3.60，CI=1.56-8.30）银屑病，特别是在美国（分别为OR=7.60，CI=2.47-23.34和OR=4.72，CI=1.43-15.56）。WC >第90百分位数发生在9.3%（n=19）的对照组、14.0%（n=27）的轻度和21.2%（n=43）的重度银屑病患者中，尤其是在美国（12.0%的对照组、20.8%的轻度和31.1%的重度银屑病患者）。银屑病儿童的腰围与身高比（0.48）显著高于对照组（0.46），但不受银屑病严重程度的影响。严重银屑病的儿童在最严重的时候，但在登记时是轻度的，与登记时仍然严重的儿童在过度肥胖或中心性肥胖方面没有差异。在全球范围内，银屑病儿童无论严重程度如何，都有过度肥胖和中心性肥胖增加。与过度和中心性肥胖相关的代谢风险增加需要早期监测和生活方式改变。
Investigate the relationship of excess and central adiposity with pediatric psoriasis severity. Multi-center, cross-sectional study of 409 psoriatic children. Psoriasis was classified as mild (worst Physician’s Global Assessment (PGA) <3 with body surface area (BSA) <10%) or severe (worst PGA >3 with BSA >10%). Children were enrolled from 9 countries July 2009-December 2011. Excess adiposity (body mass index (BMI) percentile) and central adiposity (waist circumference (WC) percentile and waist-to-height ratio). Excess adiposity (BMI >85th percentile) occurred in 37.8% (n=155) of psoriatics vs. 20.5% (n=42) of controls, but did not differ by severity. The odds of obesity (BMI >95th percentile) overall in psoriatics vs. controls were OR=4.29, 95% CI=1.96-9.39, but were higher with severe (OR=4.92, CI=2.20-10.99) than mild (OR=3.60, CI=1.56-8.30) psoriasis, particularly in the U.S. (OR=7.60, CI=2.47-23.34, and OR=4.72, CI=1.43-15.56, respectively). WC >90th percentile occurred in 9.3% (n=19) of controls, 14.0% (n=27) of mild, and 21.2% (n=43) of severe psoriatics internationally, and especially in the U.S. (12.0% of controls, 20.8% of mild, and 31.1% of severe psoriatics). Waist-to-height ratio was significantly higher in psoriatic (0.48) vs. control (0.46) children, but unaffected by psoriasis severity. Children with severe psoriasis at their worst, but mild at enrollment, showed no difference in excess or central adiposity from children who remained severe at enrollment. Globally, children with psoriasis have both excess adiposity and increased central adiposity, regardless of severity. The increased metabolic risks associated with excess and central adiposity warrant early monitoring and lifestyle modification.
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影响因子：
120.7
作者：
Gelfand, Joel M.;Neimann, Andrea L.;Troxel, Andrea B.
通讯作者：
Troxel, Andrea B.
影响因子：
4.2
作者：
de Onis, Mercedes;Garza, Cutberto;Borghi, Elaine
通讯作者：
Borghi, Elaine
影响因子：
10.3
作者：
de Jager, M. E. A.;van de Kerkhof, P. C. M.;Seyger, M. M. B.
通讯作者：
Seyger, M. M. B.
影响因子：
--
作者：
Bassali, Reda;Waller, Jennifer L.;Davis, Catherine L.
通讯作者：
Davis, Catherine L.
DOI：
10.1046/j.1467-789x.2002.00074.x
发表时间：
2002-08-01
期刊：
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Ismail, M N;Chee, S S;James, W P T
通讯作者：
James, W P T