Computational drug repurposing based on electronic health records: a scoping review.
Computational drug repurposing based on electronic health records: a scoping review.
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DOI：
10.1038/s41746-022-00617-6
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发表时间：
2022-06-14
影响因子：
15.2
通讯作者：
中科院分区：
文献类型：
--
作者：
Computational drug repurposing methods adapt Artificial intelligence (AI) algorithms for the discovery of new applications of approved or investigational drugs. Among the heterogeneous datasets, electronic health records (EHRs) datasets provide rich longitudinal and pathophysiological data that facilitate the generation and validation of drug repurposing. Here, we present an appraisal of recently published research on computational drug repurposing utilizing the EHR. Thirty-three research articles, retrieved from Embase, Medline, Scopus, and Web of Science between January 2000 and January 2022, were included in the final review. Four themes, (1) publication venue, (2) data types and sources, (3) method for data processing and prediction, and (4) targeted disease, validation, and released tools were presented. The review summarized the contribution of EHR used in drug repurposing as well as revealed that the utilization is hindered by the validation, accessibility, and understanding of EHRs. These findings can support researchers in the utilization of medical data resources and the development of computational methods for drug repurposing.
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影响因子：
4.6
作者：
Hsieh KY;Tsai JY;Lin YH;Chang FR;Wang HC;Wu CC
通讯作者：
Wu CC
影响因子：
4.5
作者：
Jang, Dongjin;Lee, Sejoon;Lee, Doheon
通讯作者：
Lee, Doheon
影响因子：
24
作者：
Cai, Tianxi;Zhang, Yichi;Liao, Katherine P.
通讯作者：
Liao, Katherine P.
影响因子：
6.7
作者：
Denny JC;Van Driest SL;Wei WQ;Roden DM
通讯作者：
Roden DM
DOI：
10.1002/wsbm.1337
发表时间：
2016-05
期刊：
Wiley interdisciplinary reviews. Systems biology and medicine
影响因子：
--
作者：
Hodos RA;Kidd BA;Shameer K;Readhead BP;Dudley JT
通讯作者：
Dudley JT