Golden berry 4β-hydroxywithanolide E prevents tumor necrosis factor α-induced procoagulant activity with enhanced cytotoxicity against human lung cancer cells.
Golden berry 4β-hydroxywithanolide E prevents tumor necrosis factor α-induced procoagulant activity with enhanced cytotoxicity against human lung cancer cells.
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DOI：
10.1038/s41598-021-84207-8
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发表时间：
2021-02-25
影响因子：
4.6
通讯作者：
Wu CC
中科院分区：
文献类型：
--
作者：
Hsieh KY;Tsai JY;Lin YH;Chang FR;Wang HC;Wu CC
Inflammation in the tumor microenvironment is positively correlated with cancer progression and metastasis as well as the risk of thromboembolism in lung cancer patients. Here we show, in human non-small cell lung cancer (NSCLC) cell lines, the master inflammatory cytokine tumor necrosis factor (TNF-α) induced tissue factor expression and procoagulant activity, and these effects were potently inhibited by 4β-hydroxywithanolide E (4HW), a natural compound isolated from Physalis peruviana. Furthermore, combination of 4HW and TNF-α caused synergistic cytotoxicity against NSCLC cells by inducing caspase-dependent apoptosis. The underlying mechanism by which 4HW reverses the procoagulant effect of TNF-α but enhances its cytotoxic effect appears to be due to inhibition of NF-κB, which is a key switch for both inflammation-induced coagulation and cell survival. Our results suggest that 4HW may have a potential application for treating inflammation-derived cancer progression and cancer-associated hypercoagulable state.
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DOI：
10.2741/3782
发表时间：
2011-01-01
期刊：
Frontiers in bioscience (Landmark edition)
影响因子：
--
作者：
Chen W;Li Z;Bai L;Lin Y
通讯作者：
Lin Y
影响因子：
7.4
作者：
Josephs SF;Ichim TE;Prince SM;Kesari S;Marincola FM;Escobedo AR;Jafri A
通讯作者：
Jafri A
影响因子：
45.3
作者：
Macbeth, Fergus;Noble, Simon;Griffiths, Gareth
通讯作者：
Griffiths, Gareth
影响因子：
3.8
作者：
Jafri SH;Shi R;Mills G
通讯作者：
Mills G
影响因子：
3.7
作者：
Malaponte G;Signorelli SS;Bevelacqua V;Polesel J;Taborelli M;Guarneri C;Fenga C;Umezawa K;Libra M
通讯作者：
Libra M