Early zebrafish development: it's in the maternal genes.
Early zebrafish development: it's in the maternal genes.
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DOI：
10.1016/j.gde.2009.06.002
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发表时间：
2009-08
影响因子：
4
通讯作者：
Mullins, Mary C.
中科院分区：
文献类型：
--
作者：
Abrams, Elliott W.;Mullins, Mary C.
在所有被研究的动物中，胚胎发育的最早阶段依赖于卵子发生过程中产生并供应给卵子的母体基因产物。根据合子转录的开始和母体基因产物的持久性，母体对胚胎发育的控制期在动物中各不相同。在脊椎动物中，由于对母体基因功能的研究比较困难和缺乏基本的分子信息，对母体调控的研究很少。然而，最近在斑马鱼中进行的母体效应筛选已经产生了40多个独特的突变体，这些突变体为早期脊椎动物发育的母体控制提供了新的分子切入点。在这里，我们讨论了最近的研究12斑马鱼突变基因，阐明胚胎发育的母体分子控制，包括动物-植物极性，卵激活，卵裂发育，身体计划形成，组织形态发生，microRNA功能和生殖细胞发育的调节进展。
The earliest stages of embryonic development in all animals examined rely on maternal gene products that are generated during oogenesis and supplied to the egg. The period of maternal control of embryonic development varies among animals according to the onset of zygotic transcription and the persistence of maternal gene products. This maternal regulation has been little studied in vertebrates, due to the difficulty in manipulating maternal gene function and lack of basic molecular information. However, recent maternal-effect screens in the zebrafish have generated more than 40 unique mutants that are providing new molecular entry points to the maternal control of early vertebrate development. Here we discuss recent studies of 12 zebrafish mutant genes that illuminate the maternal molecular controls on embryonic development, including advances in the regulation of animal-vegetal polarity, egg activation, cleavage development, body plan formation, tissue morphogenesis, microRNA function and germ cell development.
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