Cortical Thickness in Dementia with Lewy Bodies and Alzheimer's Disease: A Comparison of Prodromal and Dementia Stages.
Cortical Thickness in Dementia with Lewy Bodies and Alzheimer's Disease: A Comparison of Prodromal and Dementia Stages.
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DOI：
10.1371/journal.pone.0127396
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Taylor JP
中科院分区：
文献类型：
--
作者：
Blanc F;Colloby SJ;Philippi N;de Pétigny X;Jung B;Demuynck C;Phillipps C;Anthony P;Thomas A;Bing F;Lamy J;Martin-Hunyadi C;O'Brien JT;Cretin B;McKeith I;Armspach JP;Taylor JP
目的：评估和比较前驱型路易体痴呆（pro-DLB）、前驱型阿尔茨海默病（pro-AD）、DLB痴呆（DLB-d）、AD痴呆（AD-d）和正常衰老患者的皮质厚度（CTh）。研究参与者（28名pro-DLB，27名pro-AD，31名DLB-d，54名AD-d和33名老年对照）接受了3 Tesla T1 3D MRI和详细的临床和认知评估。我们使用FreeSurfer分析软件包测量CTh并研究各组间皮质变薄的模式。比较pro-DLB和pro-AD之间的CTh（p<0.05，FDR校正）显示pro-DLB中更多的右前额叶变薄，pro-AD中更多的双侧顶叶和左侧海马旁回变薄。前驱期患者与健康老年对照组的比较显示了相同区域的参与。在DLB-d（p<0.05，FDR校正）中，皮质变薄主要见于右侧颞顶交界处、颞叶、扣带回、眶额和外侧枕叶皮质。在AD-d中（p<0.05，FDR校正），受影响最显著的区域包括内嗅皮质、海马旁回和顶叶。AD-d和DLB-d的比较表明，在左侧内嗅皮质中，AD-d中的CTh更多（p<0.05，FDR校正）。皮质厚度是一个敏感的措施，在早期阶段的DLB不同于AD的灰质萎缩的特点模式。右前额叶受累可能是DLB前驱期的关键部位，需要进一步研究。
To assess and compare cortical thickness (CTh) of patients with prodromal Dementia with Lewy bodies (pro-DLB), prodromal Alzheimer's disease (pro-AD), DLB dementia (DLB-d), AD dementia (AD-d) and normal ageing. Study participants(28 pro-DLB, 27 pro-AD, 31 DLB-d, 54 AD-d and 33 elderly controls) underwent 3Tesla T1 3D MRI and detailed clinical and cognitive assessments. We used FreeSurfer analysis package to measure CTh and investigate patterns of cortical thinning across groups. Comparison of CTh between pro-DLB and pro-AD (p<0.05, FDR corrected) showed more right anterior insula thinning in pro-DLB, and more bilateral parietal lobe and left parahippocampal gyri thinning in pro-AD. Comparison of prodromal patients to healthy elderly controls showed the involvement of the same regions. In DLB-d (p<0.05, FDR corrected) cortical thinning was found predominantly in the right temporo-parietal junction, and insula, cingulate, orbitofrontal and lateral occipital cortices. In AD-d(p<0.05, FDR corrected),the most significant areas affected included the entorhinal cortices, parahippocampal gyri and parietal lobes. The comparison of AD-d and DLB-d demonstrated more CTh in AD-d in the left entorhinal cortex (p<0.05, FDR corrected). Cortical thickness is a sensitive measure for characterising patterns of grey matter atrophy in early stages of DLB distinct from AD. Right anterior insula involvement may be a key region at the prodromal stage of DLB and needs further investigation.
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DOI：
10.1186/alzrt274
发表时间：
2014
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Donaghy PC;McKeith IG
通讯作者：
McKeith IG
影响因子：
2.6
作者：
Aarsland, D;Mosimann, UP;McKeith, IG
通讯作者：
McKeith, IG
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
2
作者：
Fujishiro, Hiroshige;Iseki, Eizo;Sato, Kiyoshi
通讯作者：
Sato, Kiyoshi
影响因子：
9.9
作者：
Bakkour, Akram;Morris, John C.;Dickerson, Bradford C.
通讯作者：
Dickerson, Bradford C.