Rod photoreceptors drive circadian photoentrainment across a wide range of light intensities.
Rod photoreceptors drive circadian photoentrainment across a wide range of light intensities.
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DOI：
10.1038/nn.2617
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发表时间：
2010-09
影响因子：
25
通讯作者：
Hattar, Samer
中科院分区：
文献类型：
--
作者：
Altimus, Cara M.;Gueler, Ali D.;Alam, Nazia M.;Arman, A. Cyrus;Prusky, Glen T.;Sampath, Alapakkam P.;Hattar, Samer
在哺乳动物中，下丘脑中生物钟起搏器的同步是通过内在光敏感视网膜神经节细胞（ipRGCs）传递的来自眼睛的直接输入实现的。昼夜节律的光诱导可以由视杆和视锥光感受器维持，但是它们的功能性贡献以及它们作用于ipRGCs的视网膜回路尚未被充分了解。我们在缺乏功能性视杆的基因小鼠模型中，或者在视杆是唯一功能性光感受器的情况下证明，在暗视光强度下，视杆单独负责光诱导。令人惊讶的是，在明视强度下，视杆也能够驱动昼夜节律的光诱导，尽管在此强度下它们无法支持视觉引导的行为。通过使用视锥光感受器被切除的动物，我们证明在高光强度下视杆通过视锥发出信号，但在低光强度下则不是。因此，两种不同的视网膜回路驱动ipRGC功能，以在广泛的光强度范围内支持昼夜节律的光诱导。
In mammals, synchronization of the circadian pacemaker in the hypothalamus is achieved through direct input from the eyes conveyed by intrinsically photosensitive retinal ganglion cells (ipRGCs). Circadian photoentrainment can be maintained by rod and cone photoreceptors, but their functional contributions and their retinal circuits that impinge on ipRGCs are not well understood. We demonstrate in genetic mouse models lacking functional rods, or where rods are the only functional photoreceptors, that rods are solely responsible for photoentrainment at scotopic light intensities. Surprisingly, rods were also capable of driving circadian photoentrainment at photopic intensities where they were incapable of supporting a visually–guided behavior. Using animals in which cone photoreceptors were ablated, we demonstrate that rods signal through cones at high light intensities, but not low light intensities. Thus two distinct retinal circuits drive ipRGC function to support circadian photoentrainment across a wide range of light intensities.
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影响因子：
16.2
作者：
Lall, Gurprit S.;Revell, Victoria L.;Momiji, Hiroshi;Al Enezi, Jazi;Altimus, Cara M.;Gueler, Ali D.;Aguilar, Carlos;Cameron, Morven A.;Allender, Susan;Hankins, Mark W.;Lucas, Robert J.
通讯作者：
Lucas, Robert J.
影响因子：
64.8
作者：
Do, Michael Tri H.;Kang, Shin H.;Xue, Tian;Zhong, Haining;Liao, Hsi-Wen;Bergles, Dwight E.;Yau, King-Wai
通讯作者：
Yau, King-Wai
DOI：
10.1073/pnas.250478897
发表时间：
2000-12-05
影响因子：
11.1
作者：
Calvert, PD;Krasnoperova, NV;Lem, J
通讯作者：
Lem, J
影响因子：
64.8
作者：
Gueler, Ali D.;Ecker, Jennifer L.;Hattar, Samer
通讯作者：
Hattar, Samer
DOI：
10.1073/pnas.96.24.14130
发表时间：
1999-11-23
影响因子：
11.1
作者：
Hack, I;Peichl, L;Brandstätter, JH
通讯作者：
Brandstätter, JH