Effects of Elevated Maternal Adiposity on Offspring Reproductive Health: A Perspective From Epidemiologic Studies.
Effects of Elevated Maternal Adiposity on Offspring Reproductive Health: A Perspective From Epidemiologic Studies.
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孕产妇肥胖对后代生殖健康的影响：流行病学研究的观点。
DOI：
10.1210/jendso/bvac163
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发表时间：
2022-11-17
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
--
作者：
在发达国家，每七对夫妇中就有一对患有不孕症。母亲超重或肥胖对后代的心脏代谢健康具有有害和持久的影响，尽管需要更多的数据，但母亲过度肥胖导致的子宫内激素失衡也可能破坏生殖编程并影响后代未来的生殖健康。因此，本小型综述评估了人类流行病学证据，即母亲超重/肥胖可能与后代生殖健康不良结局相关。我们在PubMed中搜索相关研究，使用的术语包括“母亲肥胖”和“生殖发育”。虽然人类流行病学文献有限，但迄今为止的研究发现，孕产妇肥胖与外生殖器发育中断和整个生命周期的其他几个生殖健康标志物有关。特别是，母亲肥胖与男性尿道下裂和隐睾的风险较高，以及男性和女性肛门生殖器距离的破坏有关。母亲肥胖还与女儿初潮年龄提前以及儿子和女儿的性早熟有关。最后，超重或肥胖妇女的女儿患多囊卵巢综合征的风险更高，这对生育能力有影响。这些研究表明，在子宫内暴露于母体肥胖可能会破坏生殖系统发育，但还需要更多的证据，因为几乎没有人类流行病学研究评估了母体肥胖对后代生育力/生殖力的长期影响。
One in seven couples in developed countries suffers from infertility. Maternal overweight or obesity have detrimental and lasting effects on offspring cardiometabolic health, and although substantially more data are needed, hormonal imbalances in utero resulting from excessive maternal adiposity could also disrupt reproductive programming and affect the future reproductive health of offspring. Therefore, this mini-review evaluates the human epidemiologic evidence that maternal overweight/obesity could be associated with poor reproductive health outcomes in offspring. We searched PubMed for relevant studies using terms such as “maternal obesity” and “reproductive development.” While the human epidemiologic literature is limited, studies have thus far observed that maternal obesity is associated with disrupted external genital development and several other markers of reproductive health across the lifespan. Specifically, maternal obesity is associated with higher risks of hypospadias and cryptorchidism in males and disrupted anogenital distance both in males and females. Maternal obesity has also been linked to earlier age at menarche in daughters, and precocious puberty in both sons and daughters. Finally, daughters of women with overweight or obesity have higher risks of developing polycystic ovarian syndrome, which has implications for fertility. This body of research suggests that in utero exposure to maternal obesity could disrupt reproductive system development, but substantially more evidence is needed, as almost no human epidemiologic studies have evaluated the long-term consequences of maternal obesity with regard to offspring fertility/fecundity.
影响因子：
2.3
作者：
Deardorff J;Berry-Millett R;Rehkopf D;Luecke E;Lahiff M;Abrams B
通讯作者：
Abrams B