Maternal pre-pregnancy BMI, gestational weight gain, and age at menarche in daughters.
Maternal pre-pregnancy BMI, gestational weight gain, and age at menarche in daughters.
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DOI：
10.1007/s10995-012-1139-z
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发表时间：
2013-10
影响因子：
2.3
通讯作者：
Abrams B
中科院分区：
文献类型：
--
作者：
Deardorff J;Berry-Millett R;Rehkopf D;Luecke E;Lahiff M;Abrams B
生命历程理论表明，早期的生活经历可以影响一生和几代人的健康。母亲怀孕经历与女儿初潮年龄之间的关系尚不清楚。我们检查了母亲孕前 BMI 和妊娠体重增加 (GWG) 是否与女儿初潮年龄独立相关。与生命历程的观点一致，我们还研究了母亲的 GWG、出生体重和青春期前的 BMI 是否介导了孕前 BMI 和女儿月经初潮年龄之间的关系。我们对 1979 年全国青少年纵向调查中的 2,497 对母女进行了调查。使用 Cox 比例风险的生存分析来估计母亲孕前超重/肥胖（BMI 25.0 kg/m2）和 GWG 充足（不足、推荐和过量）是否与女孩月经初潮提前的风险相关，并控制了重要的协变量。进行分析以检验 GWG 充足性、儿童出生体重和青春期前 BMI 的中介作用。调整协变量后，孕前超重/肥胖（HR = 1.20，95% CI 1.06，1.36）和 GWG 过多（HR = 1.13，95% CI 1.01，1.27）与女儿初潮提前相关，而 GWG 不足则不然。母亲孕前体重与女儿月经初潮时间之间的关联不受女儿出生体重、青春期前BMI或母亲GWG的调节。怀孕前和怀孕期间的母亲因素是女儿月经初潮时间的潜在重要决定因素，并且易于干预。需要进一步的研究来更好地了解这些因素的运作途径。
Life course theory suggests that early life experiences can shape health over a lifetime and across generations. Associations between maternal pregnancy experience and daughters’ age at menarche are not well understood. We examined whether maternal pre-pregnancy BMI and gestational weight gain (GWG) were independently related to daughters’ age at menarche. Consistent with a life course perspective, we also examined whether maternal GWG, birth weight, and prepubertal BMI mediated the relationship between pre-pregnancy BMI and daughter's menarcheal age. We examined 2,497 mother-daughter pairs from the 1979 National Longitudinal Survey of Youth. Survival analysis with Cox proportional hazards was used to estimate whether maternal pre-pregnancy overweight/obesity (BMI 25.0 kg/m2) and GWG adequacy (inadequate, recommended, and excessive) were associated with risk for earlier menarche among girls, controlling for important covariates. Analyses were conducted to examine the mediating roles of GWG adequacy, child birth weight and prepubertal BMI. Adjusting for covariates, pre-pregnancy overweight/obesity (HR= 1.20, 95% CI 1.06, 1.36) and excess GWG (HR=1.13, 95% CI 1.01, 1.27) were associated with daughters’ earlier menarche, while inadequate GWG was not. The association between maternal pre-pregnancy weight and daughters’ menarcheal timing was not mediated by daughter's birth weight, prepubertal BMI or maternal GWG. Maternal factors, before and during pregnancy, are potentially important determinants of daughters’ menarcheal timing and are amenable to intervention. Further research is needed to better understand pathways through which these factors operate.
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影响因子：
8
作者：
Anderson, SE;Dallal, GE;Must, A
通讯作者：
Must, A
影响因子：
5
作者：
Berkey, CS;Gardner, JD;Colditz, GA
通讯作者：
Colditz, GA
影响因子：
8
作者：
Euling, Susan Y.;Herman-Giddens, Marcia E.;Swan, Shanna H.
通讯作者：
Swan, Shanna H.
影响因子：
8
作者：
Chumlea, WC;Schubert, CM;Sun, SS
通讯作者：
Sun, SS
影响因子：
5.1
作者：
Anderson, SE;Must, A
通讯作者：
Must, A