Requirement for Early-Generated Neurons Recognized by Monoclonal Antibody Lot1 in the Formation of Lateral Olfactory Tract
Requirement for Early-Generated Neurons Recognized by Monoclonal Antibody Lot1 in the Formation of Lateral Olfactory Tract
复制标题
单克隆抗体 Lot1 识别的早期神经元在侧嗅束形成中的需求
DOI：
10.1523/jneurosci.18-19-07800.1998
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
H. Fujisawa
中科院分区：
文献类型：
--
作者：
Y. Sato;T. Hirata;M. Ogawa;H. Fujisawa
在发育过程中，僧帽细胞，嗅球的主要输出神经元，将轴突投射到端脑的一个非常狭窄的部分，并形成一个称为外侧嗅束（LOT）的轴突束。目前的研究表明，在第一个二尖瓣细胞轴突伸长之前，LOT位置已经标记有一个由单克隆抗体lot1（lot细胞）识别的早期生成的神经元子集。二尖瓣细胞轴突选择LOT细胞位置进行其生长途径，并保持与细胞的紧密接触，直到LOT形成完成。LOT细胞的消融防止了器官型培养中LOT的形成。这些结果表明，lot细胞是二尖瓣细胞轴突的“路标细胞”。
During development, mitral cells, the main output neurons of the olfactory bulb, project axons into a very narrow part of the telencephalon and form an axonal bundle called the lateral olfactory tract (LOT). The present study shows that before the first mitral cell axons elongate, the LOT position is already marked with a subset of early-generated neurons that are recognized by monoclonal antibody lot1 (lot cells). Mitral cell axons choose the lot cell position for their growth pathway and maintain a close contact with the cells until LOT formation is completed. Ablation of lot cells prevented LOT formation in organotypic culture. These results suggest that lot cells are “guidepost cells” for mitral cell axons.
影响因子：
56.9
作者：
D. Sretavan;E. Puré;M. Siegel;L. Reichardt
通讯作者：
D. Sretavan;E. Puré;M. Siegel;L. Reichardt