Immune response’s enhancement via controlled drug scheduling
Immune response’s enhancement via controlled drug scheduling
复制标题
通过受控药物调度增强免疫反应
DOI：
10.1109/cdc.2007.4434462
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
A. Astolfi
中科院分区：
文献类型：
--
作者：
Hyeygjeon Chang;A. Astolfi
导致获得性免疫缺陷综合症 (AIDS) 的人类免疫缺陷病毒 (HIV) 感染是一个动态过程，可以通过微分方程进行建模。本文的主要目标是引入一种控制理念，通过药物调度来增强免疫系统的反应。控制目标是引导系统达到平衡状态，称为非进展状态，它对应于没有出现艾滋病症状的感染患者。通过对两个 HIV 动态模型和一般疾病模型的模拟说明了控制方法的可行性。
The human immunodeficiency virus (HIV) infection, that causes acquired immune deficiency syndrome (AIDS), is a dynamic process that can be modeled via differential equations. The primary goal of this paper is to introduce a control philosophy to boost the response of the immune system by means of drug scheduling. The control goal is to steer the system to an equilibrium condition, known as nonprogressor, which corresponds to an infected patient that does not develop the symptoms of AIDS. The feasibility of the control methodology is illustrated via simulations on two HIV dynamic models and on a general disease model.
影响因子：
2
作者：
Zurakowski, R;Teel, AR
通讯作者：
Teel, AR