Open-label, randomized, parallel-group controlled clinical trial of massage for treatment of depression in HIV-infected subjects.
Open-label, randomized, parallel-group controlled clinical trial of massage for treatment of depression in HIV-infected subjects.
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按摩治疗 HIV 感染者抑郁症的开放标签、随机、平行组对照临床试验。
DOI：
10.1089/acm.2012.0058
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Daar,EricS
中科院分区：
文献类型：
--
作者：
Poland,RussellE;Gertsik,Lev;Favreau,JoyaT;Smith,ShawneeI;Mirocha,JamesM;Rao,Uma;Daar,EricS
目的：研究目的是确定按摩疗法是否可以减轻患有人类免疫缺陷病毒 (HIV) 疾病的受试者的抑郁症状。设计：受试者被随机分为三个平行组之一，接受瑞典式按摩，或两个对照组之一，触摸或不干预八周。背景/地点：该研究在加利福尼亚州洛杉矶雪松西奈医疗中心的精神病学和行为神经科学部进行，该部门在一家机构中提供初级临床护理对象：研究纳入要求年龄至少 16 岁、HIV 血清阳性、诊断为重度抑郁症。受试者必须接受稳定的神经精神、镇痛和抗逆转录病毒疗法超过 30 天，并且在研究期间没有计划修改治疗方法。大约 40% 的受试者目前正在服用抗抑郁药。所有受试者的病情均稳定。五十四 (54) 名受试者被随机分配，其中 50 名完成至少 1 周（意向治疗；ITT），37 名完成研究（完成者）。 干预措施：瑞典按摩和触摸受试者每周两次拜访按摩治疗师，每次 1 小时。触摸组由按摩治疗师将双手放在受试者身上，施加轻微压力，但不进行按摩，以与按摩受试者相同的模式均匀分布。结果测量：主要结果测量是汉密尔顿抑郁量表评分，次要结果测量是贝克抑郁量表。结果：对于 ITT 和完成者分析，按摩从第 4 周开始显着降低了抑郁的严重程度 (p≤0.04)，并持续到第 6 周(p≤0.03) 和 8 (p≤0.005) 与无干预和/或触摸相比。结论：结果表明，按摩疗法可以减轻 HIV 患者的抑郁症状。反应的持久性、按摩的最佳“剂量”以及按摩发挥抗抑郁作用的机制仍有待确定。
Objectives:The study objectives were to determine whether massage therapy reduces symptoms of depression in subjects with human immunodeficiency virus (HIV) disease.Design:Subjects were randomized non-blinded into one of three parallel groups to receive Swedish massage or to one of two control groups, touch or no intervention for eight weeks.Settings/location:The study was conducted at the Department of Psychiatry and Behavioral Neurosciences at Cedars-Sinai Medical Center in Los Angeles, California, which provided primary clinical care in an institutional setting.Subjects:Study inclusion required being at least 16 years of age, HIV-seropositive, with a diagnosis of major depressive disorder. Subjects had to be on a stable neuropsychiatric, analgesic, and antiretroviral regimen for >30 days with no plans to modify therapy for the duration of the study. Approximately 40% of the subjects were currently taking antidepressants. All subjects were medically stable. Fifty-four (54) subjects were randomized, 50 completed at least 1 week (intent-to-treat; ITT), and 37 completed the study (completers).Interventions:Swedish massage and touch subjects visited the massage therapist for 1 hour twice per week. The touch group had a massage therapist place both hands on the subject with slight pressure, but no massage, in a uniform distribution in the same pattern used for the massage subjects.Outcome measures:The primary outcome measure was the Hamilton Rating Scale for Depression score, with the secondary outcome measure being the Beck Depression Inventory.Results:For both the ITT and completers analyses, massage significantly reduced the severity of depression beginning at week 4 (p≤0.04) and continuing at weeks 6 (p≤0.03) and 8 (p≤0.005) compared to no intervention and/or touch.Conclusions:The results indicate that massage therapy can reduce symptoms of depression in subjects with HIV disease. The durability of the response, optimal “dose” of massage, and mechanisms by which massage exerts its antidepressant effects remain to be determined.
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影响因子：
17.7
作者：
Kessler, RC;Soukup, J;Eisenberg, DM
通讯作者：
Eisenberg, DM
影响因子：
5.3
作者：
Hou, Wen-Hsuan;Chiang, Pai-Tsung;Yen, Yung-Chieh
通讯作者：
Yen, Yung-Chieh
Perkins博士和同事回复
影响因子：
17.7
作者：
D. Perkins;E. Davidson;J. Leserman;Duanping Liao;Dwight L. Evans
通讯作者：
Dwight L. Evans
HIV 感染者的情绪障碍：艾滋病流行非中心地区的患病率和危险因素。
DOI：
10.1176/ajp.151.2.233
发表时间：
1994
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Perkins,DO;Stern,RA;Golden,RN;Murphy,C;Naftolowitz,D;Evans,DL
通讯作者：
Evans,DL
影响因子：
5.3
作者：
Kornstein, Susan G.;Wohlreich, Madelaine M.;Stewart, Donna E.
通讯作者：
Stewart, Donna E.