Evaluation of a Balloon Implant for Simultaneous Magnetic Nanoparticle Hyperthermia and High-Dose-Rate Brachytherapy of Brain Tumor Resection Cavities.
Evaluation of a Balloon Implant for Simultaneous Magnetic Nanoparticle Hyperthermia and High-Dose-Rate Brachytherapy of Brain Tumor Resection Cavities.
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球囊植入物对脑肿瘤切除腔同时进行磁纳米粒子热疗和高剂量率近距离放射治疗的评估。
DOI：
10.3390/cancers15235683
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发表时间：
2023-12-01
期刊：
影响因子：
5.2
通讯作者：
Stauffer, Paul R.
中科院分区：
文献类型：
--
作者：
Wan, Shuying;Rodrigues, Dario B.;Kwiatkowski, Janet;Khanna, Omaditya;Judy, Kevin D.;Goldstein, Robert C.;Bloem, Marty Overbeek;Yu, Yan;Rooks, Sophia E.;Shi, Wenyin;Hurwitz, Mark D.;Stauffer, Paul R.
关键词：
胶质母细胞瘤（GBM）通常局部复发，中位生存期<18个月。热疗与放射治疗相结合可增强放射反应并改善临床结果。本研究评价了用于肿瘤切除腔同时进行热辐射治疗的热近距离放射治疗球囊植入物。数据表明，我们的原型植入物在球囊周围产生球对称的热和辐射剂量分布，而体内实验证实了我们在高度灌注猪脑组织中距球囊表面5 mm处加热≥40 °C的能力。该设备现在已经准备好完成监管批准，预计将进行早期临床研究。先前的工作已经报道了一种新型热近距离放射治疗（TBT）球囊植入物的设计，用于在脑肿瘤切除术后同时提供磁性纳米颗粒（MNP）热疗和高剂量率（HDR）近距离放射治疗，从而最大限度地发挥其协同效应。本文介绍了球囊器械的稳健性、其热量和辐射输送组件的兼容性以及TBT球囊的热量和辐射剂量测定的评价。将直径为1 cm和3 cm的TBT球囊器械放置在最大强度为8.1 kA/m（133 kHz）的外部磁场中进行评价。球囊中的MNP溶液（纳米流体）吸收能量，从而产生热量，而HDR源通过导管行进到球囊的中心以递送辐射剂量。3D打印的人类颅骨模型填充有脑组织等效凝胶，用于在四个3 cm球囊周围进行体模加热和辐射测量。对于体内实验，将直径为1cm的球囊手术植入三只活体猪（40-50 kg）的脑中。TBT球囊植入物的耐用性和坚固性，以及其热和辐射输送组件的兼容性，已在实验室研究中得到证实。纳米流体、磁场和加热至77 °C的存在并没有显著影响辐射剂量。热标测和2D红外图像显示体模和脑组织中的球对称加热。猪体内实验显示，在距离60 °C球囊表面5 mm处，能够将灌注良好的脑组织加热至高热水平（≥40 °C）。
Glioblastoma (GBM) generally recurs locally with a dismal median survival of <18 months. Combining thermal therapy with radiation therapy enhances radiation response and improves clinical outcomes. This study evaluates a thermobrachytherapy balloon implant intended for the simultaneous heat and radiation treatment of tumor resection cavities. The data demonstrate that our prototype implant produces spherically symmetric heat and radiation dose distributions around the balloon, while the in vivo experiments confirm our ability to heat ≥40 °C at a 5 mm distance from the balloon surface in highly perfused pig brain tissue. The device is now ready for the finalization of regulatory approvals in anticipation of early-stage clinical investigation. Previous work has reported the design of a novel thermobrachytherapy (TBT) balloon implant to deliver magnetic nanoparticle (MNP) hyperthermia and high-dose-rate (HDR) brachytherapy simultaneously after brain tumor resection, thereby maximizing their synergistic effect. This paper presents an evaluation of the robustness of the balloon device, compatibility of its heat and radiation delivery components, as well as thermal and radiation dosimetry of the TBT balloon. TBT balloon devices with 1 and 3 cm diameter were evaluated when placed in an external magnetic field with a maximal strength of 8.1 kA/m at 133 kHz. The MNP solution (nanofluid) in the balloon absorbs energy, thereby generating heat, while an HDR source travels to the center of the balloon via a catheter to deliver the radiation dose. A 3D-printed human skull model was filled with brain-tissue-equivalent gel for in-phantom heating and radiation measurements around four 3 cm balloons. For the in vivo experiments, a 1 cm diameter balloon was surgically implanted in the brains of three living pigs (40–50 kg). The durability and robustness of TBT balloon implants, as well as the compatibility of their heat and radiation delivery components, were demonstrated in laboratory studies. The presence of the nanofluid, magnetic field, and heating up to 77 °C did not affect the radiation dose significantly. Thermal mapping and 2D infrared images demonstrated spherically symmetric heating in phantom as well as in brain tissue. In vivo pig experiments showed the ability to heat well-perfused brain tissue to hyperthermic levels (≥40 °C) at a 5 mm distance from the 60 °C balloon surface.
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影响因子：
45.3
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