In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography.
In vivo diagnosis of plaque erosion and calcified nodule in patients with acute coronary syndrome by intravascular optical coherence tomography.
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DOI：
10.1016/j.jacc.2013.05.071
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发表时间：
2013-11-05
影响因子：
24
通讯作者：
Jang, Ik-Kyung
中科院分区：
文献类型：
--
作者：
Jia, Haibo;Abtahian, Farhad;Aguirre, Aaron D.;Lee, Stephen;Chia, Stanley;Lowe, Harry;Kato, Koji;Yonetsu, Taishi;Vergallo, Rocco;Hu, Sining;Tian, Jinwei;Lee, Hang;Park, Seung-Jung;Jang, Yang-Soo;Raffel, Owen C.;Mizuno, Kyoichi;Uemura, Shiro;Itoh, Tomonori;Kakuta, Tsunekazu;Choi, So-Yeon;Dauerman, Harold L.;Prasad, Abhiram;Toma, Catalin;McNulty, Iris;Zhang, Shaosong;Yu, Bo;Fuster, Valentine;Narula, Jagat;Virmani, Renu;Jang, Ik-Kyung
关键词：
目的应用光学相干断层扫描（OCT）观察急性冠状动脉综合征（ACS）患者斑块糜烂和钙化结节的形态学特征。斑块侵蚀和钙化结节尚未在体内进行系统研究。纳入了126例接受过干预前OCT成像的ACS患者。根据OCT新的诊断标准，罪犯病变分为斑块破裂（PR）、糜烂（OCT糜烂）、钙化结节（OCT CN）或其他。PR、OCT糜烂和OCT CN的发生率分别为43.7%、31.0%和7.9%。OCT糜烂患者与PR和OCT CN患者相比最年轻（53. 8 ± 13. 1岁vs. 60. 6 ± 11. 5岁，65. 1 ± 5. 0岁，p= 0. 005）。与PR患者相比，OCT糜烂（61.5% vs. 29.1%，p=0.008）和OCT CN（100% vs. 29.1%，p<0.001）患者的非ST段抬高ACS（NSTE-ACS）更常见。OCT糜烂组脂质斑块发生率较低（43.6% vs. 100%，p<0.001），纤维帽较厚（169.3±99.1 μm vs. 60.4±16.6 μm，p<0.001），且脂质弧较小（202.8±73.6° vs. 275.8±60.4°，OCT侵蚀组的直径狭窄最轻，其次是OCT-CN和PR（55.4±14.7% vs. 66.1±13.5% vs. 68.8± 12.9%，p<0.001）。OCT是一种很有前途的方式，用于识别OCT侵蚀和OCT CN在体内。OCT侵蚀在ACS患者中常见，尤其是在NSTE-ACS患者和年轻患者中。OCT-CN是ACS最不常见的病因，在老年患者中更常见。
To characterize the morphological features of plaque erosion and calcified nodule in patients with acute coronary syndrome (ACS) by optical coherence tomography (OCT). Plaque erosion and calcified nodule have not been systematically investigated in vivo. One hundred and twenty-six patients with ACS who had undergone pre-intervention OCT imaging were included. The culprit lesions were classified as plaque rupture (PR), erosion (OCT-erosion), calcified nodule (OCT-CN), or others using a new set of diagnostic criteria for OCT. The incidences of PR, OCT-erosion, and OCT-CN were 43.7%, 31.0%, and 7.9%, respectively. Patients with OCT-erosion were the youngest compared with those with PR and OCT-CN (53.8±13.1 years vs. 60.6±11.5 years, 65.1±5.0 years, p=0.005). Compared with patients with PR, presentation with non-ST-segment elevation ACS (NSTE-ACS) was more common in patients with OCT-erosion (61.5% vs. 29.1%, p=0.008) and OCT-CN (100% vs. 29.1%, p<0.001). OCT-erosion had a lower frequency of lipid plaque (43.6% vs. 100%, p<0.001), thicker fibrous cap (169.3±99.1 μm vs. 60.4±16.6 μm, p<0.001), and smaller lipid arc (202.8±73.6° vs. 275.8±60.4°, p<0.001) than PR. The diameter stenosis was least severe in OCT-erosion followed by OCT-CN and PR (55.4±14.7% vs. 66.1±13.5% vs. 68.8±12.9%, p<0.001). OCT is a promising modality for identifying OCT-erosion and OCT-CN in vivo. OCT-erosion is a frequent finding in patients with ACS, especially in those with NSTE-ACS and younger patients. OCT-CN is the least common etiology for ACS and is more common in older patients.
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影响因子：
24
作者：
Virmani, R;Burke, AP;Kolodgie, FD
通讯作者：
Kolodgie, FD
影响因子：
37.8
作者：
Yabushita, H;Bourna, BE;Tearney, GJ
通讯作者：
Tearney, GJ
影响因子：
5.3
作者：
Rathore, Sudhir;Terashima, Mitsuyasu;Suzuki, Takahiko
通讯作者：
Suzuki, Takahiko
影响因子：
--
作者：
Koukoulaki M;Papachristou E;Kalogeropoulou C;Papathanasiou M;Zampakis P;Vardoulaki M;Alexopoulos D;Goumenos DS
通讯作者：
Goumenos DS
DOI：
10.1016/s0735-1097(01)01799-5
发表时间：
2002-02-20
影响因子：
24
作者：
Jang, IK;Bouma, BE;Tearney, GJ
通讯作者：
Tearney, GJ