Pulse wave and vector flow Imaging for atherosclerotic disease progression in hypercholesterolemic swine.
Pulse wave and vector flow Imaging for atherosclerotic disease progression in hypercholesterolemic swine.
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DOI：
10.1038/s41598-023-32358-1
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发表时间：
2023-04-18
影响因子：
4.6
通讯作者：
Konofagou, Elisa E.
中科院分区：
文献类型：
--
作者：
Kemper, Paul;Karageorgos, Grigorios M.;Fodera, Daniella;Lee, Nicole;Meshram, Nirvedh;Weber, Rachel A.;Nauleau, Pierre;Mobadersany, Nima;Kwon, Nancy;Myers, Kristin;Konofagou, Elisa E.
动脉粥样硬化的无创监测仍然具有挑战性。脉搏波成像 (PWI) 是一种非侵入性技术，用于测量舒张压和收缩末压下的局部硬度并量化血流动力学。本研究的目的有两个，即（1）研究（适应性）PWI 评估高胆固醇猪模型中颈动脉局部硬度和均匀性渐进变化的能力；（2）评估 PWI 监测血流动力学变化和硬度相应变化的能力。本研究纳入了九只 (n=9) 高胆固醇血症猪，并进行了长达 9 个月的随访。左颈动脉结扎被用来引起血流动力学紊乱。具有可检测到的血流动力学紊乱的颈动脉在结扎后立即显示壁剪切应力降低（40-90%结扎（B组）为2.12±0.49至0.98±0.47 Pa，>90%结扎（C组）为1.82±0.25至0.49±0.46 Pa）。组织学显示8-9个月后随后形成病变，病变形成的类型取决于诱导结扎的类型，结扎更显着时，在颈动脉中观察到更复杂的斑块（C：> 90％）。 B 组和 C 组的顺应性进展似乎有所不同，C 组的顺应性增加至 2.09 ± 2.90×10−10 m2 Pa−1，而 B 组的顺应性在 8 个月时仍然较低（0.95 ± 0.94×10−10 m2 Pa−1）。总之，PWI 似乎能够监测壁剪切应力的变化并分离两种不同的进展路径，从而产生不同的顺应性。
Non-invasive monitoring of atherosclerosis remains challenging. Pulse Wave Imaging (PWI) is a non-invasive technique to measure the local stiffness at diastolic and end-systolic pressures and quantify the hemodynamics. The objective of this study is twofold, namely (1) to investigate the capability of (adaptive) PWI to assess progressive change in local stiffness and homogeneity of the carotid in a high-cholesterol swine model and (2) to assess the ability of PWI to monitor the change in hemodynamics and a corresponding change in stiffness. Nine (n=9) hypercholesterolemic swine were included in this study and followed for up to 9 months. A ligation in the left carotid was used to cause a hemodynamic disturbance. The carotids with detectable hemodynamic disturbance showed a reduction in wall shear stress immediately after ligation (2.12 ± 0.49 to 0.98 ± 0.47 Pa for 40–90% ligation (Group B) and 1.82 ± 0.25 to 0.49 ± 0.46 Pa for >90% ligation (Group C)). Histology revealed subsequent lesion formation after 8–9 months, and the type of lesion formation was dependent on the type of the induced ligation, with more complex plaques observed in the carotids with a more significant ligation (C: >90%). The compliance progression appears differed for groups B and C, with an increase in compliance to 2.09 ± 2.90×10−10 m2 Pa−1 for group C whereas the compliance of group B remained low at 8 months (0.95 ± 0.94×10−10 m2 Pa−1). In summary, PWI appeared capable of monitoring a change in wall shear stress and separating two distinct progression pathways resulting in distinct compliances.
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影响因子：
10.8
作者：
Hoogendoorn, Ayla;Kok, Annette M.;Wentzel, Jolanda J.
通讯作者：
Wentzel, Jolanda J.
影响因子：
10.6
作者：
Baranger, Jerome;Arnal, Bastien;Demene, Charlie
通讯作者：
Demene, Charlie
影响因子：
24
作者：
Bos, Daniel;Arshi, Banafsheh;van der Lugt, Aad
通讯作者：
van der Lugt, Aad
影响因子：
2.9
作者：
Maksuti, Elira;Widman, Erik;Bjallmark, Anna
通讯作者：
Bjallmark, Anna
DOI：
10.1016/j.jmbbm.2014.12.004
发表时间：
2015-03-01
影响因子：
3.9
作者：
Chai, Chen-Ket;Akyildiz, Ali C.;Baaijens, Frank P. T.
通讯作者：
Baaijens, Frank P. T.