Overexpression of Long Non-Coding RNA Linc01315 Predicts Poor Prognosis in Breast Cancer.
Overexpression of Long Non-Coding RNA Linc01315 Predicts Poor Prognosis in Breast Cancer.
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长非编码 RNA Linc01315 的过度表达预示着乳腺癌的不良预后
DOI：
10.3389/fonc.2021.562378
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发表时间：
2021
影响因子：
4.7
通讯作者：
Chi Y
中科院分区：
文献类型：
--
作者：
Xue J;Huang S;Chen J;Chen YZ;Shao ZM;Wu J;Chi Y
研究背景LncRNA在肿瘤的发生、发展过程中起着重要的调控作用。使用lncRNA预测癌症治疗的预后和治疗反应已引起关注，但lncRNA的预测价值仍有待探索，其潜在机制尚未完全理解。方法采用定量RT-PCR方法检测282例乳腺癌组织中Linc 01315的表达水平。进一步分析这些乳腺癌患者的临床病理特征与Linc 01315表达水平之间的关系。采用多元回归分析评价Linc 01315对患者预后的预测价值。结果Linc 01315的表达水平与血管浸润（P = 0.028）和肿瘤亚型（P = 0.039）显著相关。Kaplan-Meier生存曲线显示，Linc 01315表达水平较低的患者的无病生存期（DFS）（P = 0.002）和总生存期（OS）（P=0.019）显著延长。多元回归分析显示，Linc 01315水平可作为DFS（危险比= 0.613，95%可信区间= 0.375-1.003; P = 0.049）和OS（危险比= 0.439，95%可信区间= 0.228-0.845; P = 0.014）的独立预测因素。进一步分析表明，低水平的Linc 01315对内分泌治疗患者的DFS（P=0.037）和OS（P=0.025）有明显的益处。结论Linc 01315表达水平与乳腺癌患者的预后密切相关。Linc 01315可能是乳腺癌独立的预后标志物和治疗靶点。
Background LncRNAs have been shown to play critical roles in regulating tumorigenesis and tumor progression. Using LncRNAs to predict prognosis and therapeutic response to cancer treatment has been caused for concern, but the predictive value of lncRNAs remains to be explored and underlying mechanisms have not been completely understood. Methods The Linc01315 expression level was detected in 282 breast cancer tissues by using quantitative RT-PCR. The association between Linc01315 expression level and clinicopathological features of these breast cancer patients was further analyzed. Multiple regression analysis was used to evaluate Linc01315 predictive value of patients’ prognosis. Results Our study revealed that Linc01315 expression level was significantly correlated with vessel invasion (P = 0.028) and tumor subtype (P = 0.039). The Kaplan–Meier survival curves demonstrated that patients with lower Linc01315 expression level had significantly longer disease free survival (DFS) (P = 0.002) and overall survival (OS) (P=0.019). Multiple regression analysis showed that Linc01315 level could be an independent predictive factor for DFS (hazards ratio = 0.613, 95% confidence interval = 0.375-1.003; P = 0.049) and OS (hazards ratio = 0.439, 95% confidence interval = 0.228-0.845; P = 0.014). Further analysis showed that low Linc01315 level patients with endocrine therapy could benefit patients DFS (P=0.037) and OS (P=0.025). Conclusion Our results demonstrate that Linc01315 expression level is significantly correlated with breast cancer patients’ prognosis. Linc01315 may represent an independent prognostic marker and therapeutic target in breast cancer.
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影响因子：
8.8
作者：
Takahashi, Y.;Sawada, G.;Kurashige, J.;Uchi, R.;Matsumura, T.;Ueo, H.;Takano, Y.;Eguchi, H.;Sudo, T.;Sugimachi, K.;Yamamoto, H.;Doki, Y.;Mori, M.;Mimori, K.
通讯作者：
Mimori, K.
影响因子：
50.3
作者：
Yan X;Hu Z;Feng Y;Hu X;Yuan J;Zhao SD;Zhang Y;Yang L;Shan W;He Q;Fan L;Kandalaft LE;Tanyi JL;Li C;Yuan CX;Zhang D;Yuan H;Hua K;Lu Y;Katsaros D;Huang Q;Montone K;Fan Y;Coukos G;Boyd J;Sood AK;Rebbeck T;Mills GB;Dang CV;Zhang L
通讯作者：
Zhang L
影响因子：
3.7
作者：
Liu H;Wang G;Yang L;Qu J;Yang Z;Zhou X
通讯作者：
Zhou X
影响因子：
39.3
作者：
Ounzain S;Micheletti R;Beckmann T;Schroen B;Alexanian M;Pezzuto I;Crippa S;Nemir M;Sarre A;Johnson R;Dauvillier J;Burdet F;Ibberson M;Guigó R;Xenarios I;Heymans S;Pedrazzini T
通讯作者：
Pedrazzini T
影响因子：
11.5
作者：
Fan, Yu;Shen, Bing;Liu, Yong
通讯作者：
Liu, Yong