Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems.
Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems.
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DOI：
10.3390/ijms22115797
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发表时间：
2021-05-28
影响因子：
5.6
通讯作者：
Darmani NA
中科院分区：
文献类型：
--
作者：
Zhong W;Shahbaz O;Teskey G;Beever A;Kachour N;Venketaraman V;Darmani NA
恶心和呕吐是常见的胃肠道疾病，可由中枢和/或外周神经系统的各种催吐刺激引发。恶心和呕吐都被认为是当威胁性毒素/药物/细菌/病毒/真菌通过肠道（例如，胃肠道）或肠胃外途径，包括血液、皮肤和呼吸系统。虽然呕吐是胃肠道内容物的强力清除行为，但恶心被认为是一种主观感觉，在非人类物种中更难以研究。在这篇综述中，作者讨论了解剖结构，神经递质/介质，和相应的受体，以及细胞内呕吐信号通路参与的过程中恶心和呕吐在不同的动物模型以及人类。虽然在预防呕吐的呕吐受体的封锁是相当好的理解，潜在的新类别的止吐药改变postreceptor信号转导机制目前正在发展，这也是审查。最后，将讨论该领域内的未来方向，仍然有待解决的重要问题和技术进步，可能有助于提供潜在的答案。
Nausea and vomiting are common gastrointestinal complaints that can be triggered by diverse emetic stimuli through central and/or peripheral nervous systems. Both nausea and vomiting are considered as defense mechanisms when threatening toxins/drugs/bacteria/viruses/fungi enter the body either via the enteral (e.g., the gastrointestinal tract) or parenteral routes, including the blood, skin, and respiratory systems. While vomiting is the act of forceful removal of gastrointestinal contents, nausea is believed to be a subjective sensation that is more difficult to study in nonhuman species. In this review, the authors discuss the anatomical structures, neurotransmitters/mediators, and corresponding receptors, as well as intracellular emetic signaling pathways involved in the processes of nausea and vomiting in diverse animal models as well as humans. While blockade of emetic receptors in the prevention of vomiting is fairly well understood, the potential of new classes of antiemetics altering postreceptor signal transduction mechanisms is currently evolving, which is also reviewed. Finally, future directions within the field will be discussed in terms of important questions that remain to be resolved and advances in technology that may help provide potential answers.
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影响因子：
5.2
作者：
Bauer T;Sipos W;Stark TD;Käser T;Knecht C;Brunthaler R;Saalmüller A;Hofmann T;Ehling-Schulz M
通讯作者：
Ehling-Schulz M
影响因子：
3.6
作者：
Wang, Yaozhi;Ray, Andrew P.;McClanahan, Bryan A.;Darmani, Nissar A.
通讯作者：
Darmani, Nissar A.
影响因子：
4.2
作者：
Barajas, Margarita;Andrade, Arturo;Arias-Montano, Jose-Antonio
通讯作者：
Arias-Montano, Jose-Antonio
影响因子：
9.3
作者：
Belkacemi L;Darmani NA
通讯作者：
Darmani NA
DOI：
10.1073/pnas.1804938115
发表时间：
2018-08-07
影响因子：
11.1
作者：
Alcaino C;Knutson KR;Treichel AJ;Yildiz G;Strege PR;Linden DR;Li JH;Leiter AB;Szurszewski JH;Farrugia G;Beyder A
通讯作者：
Beyder A