The antiemetic interaction of Delta9-tetrahydrocannabinol when combined with tropisetron or dexamethasone in the least shrew.
The antiemetic interaction of Delta9-tetrahydrocannabinol when combined with tropisetron or dexamethasone in the least shrew.
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DOI：
10.1016/j.pbb.2008.08.008
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发表时间：
2009-01
影响因子：
3.6
通讯作者：
Darmani, Nissar A.
中科院分区：
文献类型：
--
作者：
Wang, Yaozhi;Ray, Andrew P.;McClanahan, Bryan A.;Darmani, Nissar A.
5-HT3受体拮抗剂(如托烷司琼)联合地塞米松治疗顺铂(CIS)引起的急性呕吐是有效的。本研究确定了Δ9-THC与托烷司琼或地塞米松(地塞米松)合用时可能的相加或协同止吐效果。Δ9-THc(0-10 mg/kg ip)与托烷司琼(0-5 mg/kg)联合注射。或地塞米松(0-20 mg/kg ip)。阿司匹林(20 mg/kg i.p.)在最小的地鼠，诱导呕吐被记录了60分钟。单独使用Δ9-THc(减少59-97%)和托烷司琼(减少79-100%)可剂量依赖性地显著减少顺式药物引起的呕吐，但不能减少地塞米松(26-40%)，尽管有减少呕吐频率的趋势(p<；.1)。低剂量地塞米松(0.025.2 5、0.1、0.2 5 mg/kg)与低剂量托烷司琼(0.025、0.1、0.2 5 mg/kg)合用时，可明显减少呕吐次数，但Δ9-THC与地塞米松无明显的止吐作用。然而，没有一种测试组合比单独给药对动物呕吐数量的影响要大得多。Δ9-THC与托烷司琼的适度相互作用表明它们激活了重叠的止吐机制，而与地塞米松缺乏相互作用则需要进一步澄清。
5-HT3 receptor antagonists (e.g. tropisetron) combined with dexamethasone are effective for the acute phase of cisplatin (CIS)-induced emesis. This study determined the possible additive or synergistic antiemetic efficacy of Δ9-THC when combined with tropisetron or dexamethasone (DEX). Δ9-THC (0 – 10 mg/kg i.p.) was injected in combination with tropisetron (0 – 5 mg/kg i.p.) or dexamethasone (0 – 20 mg/kg i.p.) prior to CIS (20 mg/kg i.p.) in the least shrew, and the induced emesis was recorded for 60 minutes. CIS-induced vomiting was dose-dependently and significantly attenuated by individual administration of Δ9-THC (59–97% reductions) and tropisetron (79–100% attenuation), but not dexamethasone (26–40%), although a trend (p < .1) towards reduced vomiting frequency following DEX was noted. Low doses of Δ9-THC (0.25 or 0.5 mg/kg) when combined with low doses of tropisetron (0.025, 0.1, or 0.25 mg/kg) were more efficacious in reducing emesis frequency than when given individually, but Δ9-THC had no antiemetic interactions with DEX. However, no tested combination provided a significantly greater effect on the number of animals vomiting than their individually-administered counterparts. The modest interaction of Δ9-THC with tropisetron suggests they activate overlapping antiemetic mechanisms, while the lack of interaction with dexamethasone needs further clarification.
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DOI：
10.1016/0277-5379(83)90418-2
发表时间：
1983-01-01
期刊：
EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY
影响因子：
--
作者：
COATES, A;ABRAHAM, S;TATTERSALL, MHN
通讯作者：
TATTERSALL, MHN
影响因子：
3.4
作者：
Cross-Mellor, Shelley K.;Ossenkopp, Klaus-Peter;Parker, Linda A.
通讯作者：
Parker, Linda A.
DOI：
10.1016/s0306-3623(98)00102-5
发表时间：
1998-11-01
期刊：
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM
影响因子：
--
作者：
Fukunaka, N;Sagae, S;Minami, M
通讯作者：
Minami, M
影响因子：
2.9
作者：
GARB, S
通讯作者：
GARB, S
影响因子：
5
作者：
Darmani, NA;Johnson, JC
通讯作者：
Johnson, JC