Bile reflux and bile acids in the progression of gastric intestinal metaplasia.
Bile reflux and bile acids in the progression of gastric intestinal metaplasia.
复制标题
胃肠化生进展中的胆汁反流和胆汁酸
DOI：
10.1097/cm9.0000000000002290
复制
发表时间：
2022-07-20
影响因子：
6.1
通讯作者：
中科院分区：
文献类型：
--
作者：
摘要胃肠道上皮化生（GIM）是胃癌的癌前病变，被认为是胃癌不可逆的进展点。幽门螺杆菌感染可引起胃肠道动力学紊乱，但根除幽门螺杆菌仍不能逆转这一过程。胆汁反流也是GIM的致病因素，可持续刺激胃粘膜，反流液中的胆汁酸已被广泛报道与GIM相关。本文就胆汁反流与GIM的关系及胆汁酸诱导GIM的机制作一综述。
Abstract Gastric intestinal metaplasia (GIM) is a precancerous lesion of gastric cancer (GC) and is considered an irreversible point of progression for GC. Helicobacter pylori infection can cause GIM, but its eradication still does not reverse the process. Bile reflux is also a pathogenic factor in GIM and can continuously irritate the gastric mucosa, and bile acids in refluxed fluid have been widely reported to be associated with GIM. This paper reviews in detail the relationship between bile reflux and GIM and the mechanisms by which bile acids induce GIM.
影响因子：
8.8
作者：
Wu, M S;Shun, C T;Lee, W C;Chen, C J;Wang, H P;Lee, W J;Lin, J T
通讯作者：
Lin, J T