Gender differences in plasma biomarker levels in a cohort of COPD patients: a pilot study.
Gender differences in plasma biomarker levels in a cohort of COPD patients: a pilot study.
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DOI：
10.1371/journal.pone.0016021
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发表时间：
2011-01-18
期刊：
影响因子：
3.7
通讯作者：
Celli BR
中科院分区：
文献类型：
--
作者：
de Torres JP;Casanova C;Pinto-Plata V;Varo N;Restituto P;Cordoba-Lanus E;Baz-Dávila R;Aguirre-Jaime A;Celli BR
关于慢性阻塞性肺疾病（COPD）患者血浆生物标志物水平的性别差异知之甚少。女性和男性COPD患者的血清生物标志物水平存在差异。探索COPD患者和非COPD吸烟者血浆生物标志物水平的性别差异。我们检测了80例无COPD的吸烟者（男40例，女40例）和152例有类似气流阻塞的稳定期COPD患者（男76例，女76例）的血浆IL-6、IL-8、IL-16、MCP-1、MMP-9、PARC和VEGF水平。我们测定了人体测量学、吸烟史、肺功能、运动耐量、身体成分、BODE指数、合并症和生活质量。然后，我们探讨了血浆生物标志物水平与患者临床特征之间的相关性，以及与已知可预测COPD结局的临床和生理变量之间的相关性。探索的血浆生物标志物水平在无COPD的男性和女性中相似。相比之下，在COPD患者中，女性和男性的IL-6（6.26 vs 8.0，p = 0.03）、IL-16（390 vs 321，p = 0.009）和VEGF（50 vs 87，p = 0.02）的中位值不同。 校正吸烟史后，性别与IL-16、PARC和VEGF水平独立相关。IL-6、IL-16和VEGF与预测结果的生理变量之间的关联也存在性别差异。在具有相似气流阻塞的稳定期COPD患者中，血浆生物标志物水平以及生物标志物水平与重要临床或生理变量之间的关联存在性别差异。进一步的研究将证实我们的发现。
Little is known about gender differences in plasma biomarker levels in patients with chronic obstructive pulmonary disease (COPD). There are differences in serum biomarker levels between women and men with COPD. Explore gender differences in plasma biomarker levels in patients with COPD and smokers without COPD. We measured plasma levels of IL-6, IL-8, IL-16, MCP-1, MMP-9, PARC and VEGF in 80 smokers without COPD (40 males, 40 females) and 152 stable COPD patients (76 males, 76 females) with similar airflow obstruction. We determined anthropometrics, smoking history, lung function, exercise tolerance, body composition, BODE index, co-morbidities and quality of life. We then explored associations between plasma biomarkers levels and the clinical characteristics of the patients and also with the clinical and physiological variables known to predict outcome in COPD. The plasma biomarkers level explored were similar in men and women without COPD. In contrast, in patients with COPD the median value in pg/mL of IL-6 (6.26 vs 8.0, p = 0.03), IL-16 (390 vs 321, p = 0.009) and VEGF (50 vs 87, p = 0.02) differed between women and men. Adjusted for smoking history, gender was independently associated with IL-16, PARC and VEGF levels. There were also gender differences in the associations between IL-6, IL-16 and VEGF and physiologic variables that predict outcomes. In stable COPD patients with similar airflow obstruction, there are gender differences in plasma biomarker levels and in the association between biomarker levels and important clinical or physiological variables. Further studies should confirm our findings.
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DOI：
10.1186/1476-9255-7-11
发表时间：
2010-02-13
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Marwick JA;Edirisinghe I;Arunachalam G;Stevenson CS;Macnee W;Kirkham PA;Rahman I
通讯作者：
Rahman I
DOI：
10.1164/rccm.200406-754oc
发表时间：
2004-12-15
影响因子：
24.7
作者：
Bolton, CE;Ionescu, AA;Shale, DJ
通讯作者：
Shale, DJ
影响因子：
120.7
作者：
Jemal, A;Ward, E;Thun, M
通讯作者：
Thun, M
影响因子：
10
作者：
Pinto-Plata, Victor;Toso, John;Celli, Bartolome
通讯作者：
Celli, Bartolome
影响因子：
9.6
作者：
de Torres, JP;Casanova, C;Celli, BR
通讯作者：
Celli, BR