From cholera to corals: Viruses as drivers of virulence in a major coral bacterial pathogen
From cholera to corals: Viruses as drivers of virulence in a major coral bacterial pathogen
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从霍乱到珊瑚：病毒是主要珊瑚细菌病原体毒力的驱动因素
DOI：
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发表时间：
2015
影响因子：
4.6
通讯作者：
Madeleine J. H. van Oppen
中科院分区：
文献类型：
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作者：
Karen D. Weynberg;C. Voolstra;M. Neave;P. Buerger;Madeleine J. H. van Oppen
疾病对造礁珊瑚的威胁越来越大。珊瑚病为数不多的病原体之一是珊瑚弧菌。在霍乱弧菌中，细菌病毒（噬菌体）的感染导致非致病性菌株转化为致病性菌株，这可能导致霍乱大流行。霍乱弧菌基因组编码的致病性岛在发病过程中起着重要作用。在这里，我们分析了珊瑚弧菌的五个全基因组序列，以检查毒力是否同样由水平获得的元件驱动。我们证明编码毒素基因的噬菌体基因组与致病性霍乱弧菌中发现的同源基因被整合到珊瑚弧菌基因组中。在某些菌株中也存在位于染色体致病性岛上的毒力因子。这些遗传特征的存在表明珊瑚弧菌的毒力是由前噬菌体和其他水平获得的元素驱动的。珊瑚病病原体的筛选应以这些元素的保守区域为目标。
Disease is an increasing threat to reef-building corals. One of the few identified pathogens of coral disease is the bacterium Vibrio coralliilyticus. In Vibrio cholerae, infection by a bacterial virus (bacteriophage) results in the conversion of non-pathogenic strains to pathogenic strains and this can lead to cholera pandemics. Pathogenicity islands encoded in the V. cholerae genome play an important role in pathogenesis. Here we analyse five whole genome sequences of V. coralliilyticus to examine whether virulence is similarly driven by horizontally acquired elements. We demonstrate that bacteriophage genomes encoding toxin genes with homology to those found in pathogenic V. cholerae are integrated in V. coralliilyticus genomes. Virulence factors located on chromosomal pathogenicity islands also exist in some strains of V. coralliilyticus. The presence of these genetic signatures indicates virulence in V. coralliilyticus is driven by prophages and other horizontally acquired elements. Screening for pathogens of coral disease should target conserved regions in these elements.
影响因子：
56.9
作者：
Harvell, CD;Kim, K;Vasta, GR
通讯作者：
Vasta, GR
影响因子：
4.5
作者：
C. Sheridan;E. Kramarsky-Winter;M. Sweet;A. Kushmaro;M. Leal
通讯作者：
C. Sheridan;E. Kramarsky-Winter;M. Sweet;A. Kushmaro;M. Leal
DOI：
10.1073/pnas.96.3.1071
发表时间：
1999-02-02
影响因子：
11.1
作者：
Lin, W;Fullner, KJ;Mekalanos, JJ
通讯作者：
Mekalanos, JJ