Both In Situ and Circulating SLC3A2 Could Be Used as Prognostic Markers for Human Lung Squamous Cell Carcinoma and Lung Adenocarcinoma.
Both In Situ and Circulating SLC3A2 Could Be Used as Prognostic Markers for Human Lung Squamous Cell Carcinoma and Lung Adenocarcinoma.
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原位和循环SLC3A2均可作为肺鳞癌和肺腺癌的预后标志物。
DOI：
10.3390/cancers14215191
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发表时间：
2022-10-22
期刊：
影响因子：
5.2
通讯作者：
Xia, Pu
中科院分区：
文献类型：
--
作者：
Liu, Dahua;An, Min;Wen, Guimin;Xing, Yanan;Xia, Pu
随着诊疗技术的不断进步，肺癌的早期诊断率和生存率都有所提高，但肺癌的发病率和死亡率仍然很高。因此，分析肺癌发生的分子机制，确定与早期诊断相关的标志物已成为一个迫切需要解决的问题。SLC 3A 2蛋白是一种在肿瘤发生发展中起重要作用的细胞表面标志物，有望成为肿瘤治疗的新靶点。SLC 3A 2的深入研究可为肺癌的早期诊断、治疗和预后提供新的分子靶点。SLC 3A 2是CD 98蛋白的重链，在许多癌症中高度表达，包括肺癌。它通过整合素信号通路调节癌细胞的增殖和转移。液体活检是一种新的肿瘤诊断方法。血清SLC 3A 2在肺癌诊断和预后中的作用尚不清楚。在这项研究中，我们分析了SLC 3A 2 mRNA水平在人肺鳞状细胞癌（LUSC）和肺腺癌（LUAD）使用TCGA数据库和血清SLC 3A 2蛋白水平使用ELISA。我们证实了LUAD和LUSC患者的血清和组织中的高SLC 3A 2水平。血清和组织中的SLC 3A 2可作为整体LUAD和LUSC患者亚组的预后标志物。SLC 3A 2通过MEK/ERK信号通路诱导LUAD和LUSC细胞的肿瘤发生。
With the continuous progress of diagnosis and treatment technology, the early diagnosis rate and survival rate of lung cancer have improved, but the incidence rate and mortality rate of lung cancer are still very high. Therefore, it has become an urgent problem to analyze the molecular mechanism of lung cancer and to determine the markers related to early diagnosis. SLC3A2 protein is a cell-surface marker that plays an important role in tumorigenesis and development, and it is expected to become a new target for the treatment of tumors. The in-depth study of SLC3A2 can provide a new molecular target for the early diagnosis, treatment, and prognosis of lung cancer. SLC3A2, the heavy chain of the CD98 protein, is highly expressed in many cancers, including lung cancer. It can regulate the proliferation and the metastasis of cancer cells via the integrin signaling pathway. Liquid biopsy is a novel method for tumor diagnosis. The diagnostic or prognostic roles of serum SLC3A2 in lung cancer are still not clear. In this study, we analyzed SLC3A2 mRNA levels in human lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) using the TCGA database and serum SLC3A2 protein levels using ELISA. We confirmed high SLC3A2 levels in both the serum and tissue of LUAD and LUSC patients. Both serum and tissue SLC3A2 could be used as prognostic markers for overall LUAD and subgroups of LUSC patients. SLC3A2 induced tumorigenesis via the MEK/ERK signaling pathway in LUAD and LUSC cells.
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影响因子：
2.5
作者：
Rusch, Valerie W.
通讯作者：
Rusch, Valerie W.
DOI：
10.1016/j.biocel.2016.11.005
发表时间：
2016-12-01
影响因子：
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影响因子：
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作者：
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通讯作者：
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