Transcriptome of the human retina, retinal pigmented epithelium and choroid.
Transcriptome of the human retina, retinal pigmented epithelium and choroid.
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DOI：
10.1016/j.ygeno.2015.01.008
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发表时间：
2015-05
期刊：
影响因子：
4.4
通讯作者：
Stambolian DE
中科院分区：
文献类型：
--
作者：
Tian L;Kazmierkiewicz KL;Bowman AS;Li M;Curcio CA;Stambolian DE
视网膜及其邻近的支持组织--视网膜色素上皮(RPE)和脉络膜--是人眼正常视觉所必需的重要结构。这些层的异常变化与老年性黄斑变性和青光眼等疾病有关。随着基因表达序列分析、基因芯片和RNA测序等高通量方法的出现，为我们理解正常的视网膜、RPE和脉络膜提供了前所未有的机会。这一信息可用于识别老年性黄斑变性和青光眼的功能障碍。在这篇综述中，我们描述了我们通过使用高通量技术来理解这些转录本的现状。
The retina and its adjacent supporting tissues -- retinal pigmented epithelium (RPE) and choroid -- are critical structures in human eyes required for normal visual perception. Abnormal changes in these layers have been implicated in diseases such as age-related macular degeneration and glaucoma. With the advent of high-throughput methods, such as serial analysis of gene expression, cDNA microarray, and RNA sequencing, there is unprecedented opportunity to facilitate our understanding of the normal retina, RPE, and choroid. This information can be used to identify dysfunction in age-related macular degeneration and glaucoma. In this review, we describe the current status in our understanding of these transcriptomes through the use of high throughput techniques.
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影响因子：
9.8
作者：
Heinzen EL;Ge D;Cronin KD;Maia JM;Shianna KV;Gabriel WN;Welsh-Bohmer KA;Hulette CM;Denny TN;Goldstein DB
通讯作者：
Goldstein DB
影响因子：
4.4
作者：
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通讯作者：
Webster, Andrew R.
影响因子：
4.4
作者：
Curcio, Christine A.;Messinger, Jeffrey D.;Spaide, Richard F.
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Spaide, Richard F.
影响因子：
30.8
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通讯作者：
Abecasis, Goncalo R.
影响因子：
4.4
作者：
Olsen, TW;Feng, X
通讯作者：
Feng, X