Biocompatibility of the fiberoptic microneedle device chronically implanted in the rat brain.
Biocompatibility of the fiberoptic microneedle device chronically implanted in the rat brain.
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DOI：
10.1016/j.rvsc.2021.12.018
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发表时间：
2022-03
影响因子：
2.4
通讯作者：
Rossmeisl JH
中科院分区：
文献类型：
--
作者：
Kani Y;Hinckley J;Robertson JL;Mehta JM;Rylander CG;Rossmeisl JH
光纤微针装置（FMD）是一种熔融石英微导管，能够共同输送流体和光，已开发用于胶质母细胞瘤的对流增强输送和光热治疗。在这里，我们调查的生物相容性FMD片段长期植入大鼠大脑中的背景下，评估潜在的机械设备故障。Fischer大鼠进行颅骨切除术，用于假手术对照（n=16）或脑内FMD植入（n=16）。植入后每天检查大鼠，并在植入后14、30、90和180天通过头部计算机断层扫描、血液学和血液生化分析以及尸检进行评价。未观察到疾病和远端植入物迁移的临床体征，并且在任何时间，对照组和FMD植入组之间的血液分析均无差异。在所有组中均观察到局限于脑内治疗部位的轻度炎症和星形胶质细胞反应，在第30天和第90天，FMD植入组与对照组相比更强烈，并且在研究的第90-180天严重程度降低。一只大鼠出现了归因于FMD二氧化硅植入物的慢性浅表手术部位脓肉芽肿。长期植入的FMD碎片在临床上耐受性良好，并导致预期的轻度局部脑组织反应，与脑内其他植入生物材料相当。
The fiberoptic microneedle device (FMD) is a fused-silica microcatheter capable of co-delivery of fluids and light that has been developed for convection-enhanced delivery and photothermal treatments of glioblastoma. Here we investigate the biocompatibility of FMD fragments chronically implanted in the rat brain in the context of evaluating potential mechanical device failure. Fischer rats underwent craniectomy procedures for sham control (n=16) or FMD implantation (n=16) within the brain. Rats were examined daily after implantation, and at 14, 30, 90, and 180 days after implantation were evaluated via computed tomography of the head, hematologic and blood biochemical profiling, and necropsy examinations. Clinical signs of illness and distant implant migration were not observed, and blood analyses were not different between control and FMD implanted groups at any time. Mild inflammatory and astrogliotic reactions localized to the treatment sites within the brain were observed in all groups, more robust in FMD implanted groups compared to controls at days 30 and 90, and decreased in severity over days 90–180 of the study. One rat developed a chronic, superficial surgical site pyogranuloma attributed to the FMD silica implant. Chronically implanted FMD fragments were well tolerated clinically and resulted in anticipated mild, localized brain tissue responses that were comparable with other implanted biomaterials in the brain.
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DOI：
10.1093/noajnl/vdaa107
发表时间：
2020-01
期刊：
Neuro-oncology advances
影响因子：
--
作者：
Sharma P;Sonawane P;Herpai D;D'Agostino R;Rossmeisl J;Tatter S;Debinski W
通讯作者：
Debinski W
影响因子：
2.4
作者：
Hood, R. Lyle;Andriani, Rudy T., Jr.;Rossmeisl, John H., Jr.
通讯作者：
Rossmeisl, John H., Jr.
影响因子：
15.9
作者：
Vogelbaum, Michael A.;Aghi, Manish K.
通讯作者：
Aghi, Manish K.
影响因子：
2.4
作者：
Barua, N. U.;Lowis, S. P.;Gill, S. S.
通讯作者：
Gill, S. S.
影响因子：
1.5
作者：
Butt, Mark T.
通讯作者：
Butt, Mark T.