E3 Ubiquitin ligase NEDD4 family‑regulatory network in cardiovascular disease.
E3 Ubiquitin ligase NEDD4 family‑regulatory network in cardiovascular disease.
复制标题
E3 泛素连接酶 NEDD4 家族 — 心血管疾病的调控网络
DOI：
10.7150/ijbs.48437
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发表时间：
2020
影响因子：
9.2
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Zhang Y;Qian H;Wu B;You S;Wu S;Lu S;Wang P;Cao L;Zhang N;Sun Y
Protein ubiquitination represents a critical modification occurring after translation. E3 ligase catalyzes the covalent binding of ubiquitin to the protein substrate, which could be degraded. Ubiquitination as an important protein post-translational modification is closely related to cardiovascular disease. The NEDD4 family, belonging to HECT class of E3 ubiquitin ligases can recognize different substrate proteins, including PTEN, ENaC, Nav1.5, SMAD2, PARP1, Septin4, ALK1, SERCA2a, TGFβR3 and so on, via the WW domain to catalyze ubiquitination, thus participating in multiple cardiovascular-related disease such as hypertension, arrhythmia, myocardial infarction, heart failure, cardiotoxicity, cardiac hypertrophy, myocardial fibrosis, cardiac remodeling, atherosclerosis, pulmonary hypertension and heart valve disease. However, there is currently no review comprehensively clarifying the important role of NEDD4 family proteins in the cardiovascular system. Therefore, the present review summarized recent studies about NEDD4 family members in cardiovascular disease, providing novel insights into the prevention and treatment of cardiovascular disease. In addition, assessing transgenic animals and performing gene silencing would further identify the ubiquitination targets of NEDD4. NEDD4 quantification in clinical samples would also constitute an important method for determining NEDD4 significance in cardiovascular disease.
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影响因子：
49.6
作者：
Bui, Anh L.;Horwich, Tamara B.;Fonarow, Gregg C.
通讯作者：
Fonarow, Gregg C.
影响因子：
--
作者：
Baptista R;Meireles J;Agapito A;Castro G;da Silva AM;Shiang T;Gonçalves F;Robalo-Martins S;Nunes-Diogo A;Reis A
通讯作者：
Reis A
DOI：
10.1177/1535370214566558
发表时间：
2015-03
期刊：
Experimental biology and medicine (Maywood, N.J.)
影响因子：
--
作者：
Dodson EJ;Fishbain-Yoskovitz V;Rotem-Bamberger S;Schueler-Furman O
通讯作者：
Schueler-Furman O
DOI：
10.1073/pnas.95.18.10602
发表时间：
1998-09-01
影响因子：
11.1
作者：
Bedford, MT;Reed, R;Leder, P
通讯作者：
Leder, P
影响因子：
56.9
作者：
CHAU, V;TOBIAS, JW;VARSHAVSKY, A
通讯作者：
VARSHAVSKY, A