Somatosensory information processing in the aging population.
Somatosensory information processing in the aging population.
复制标题
老龄化人群中的体感信息处理。
DOI：
10.3389/fnagi.2011.00018
复制
发表时间：
2011
影响因子：
4.8
通讯作者：
Tommerdahl M
中科院分区：
文献类型：
--
作者：
Zhang Z;Francisco EM;Holden JK;Dennis RG;Tommerdahl M
众所周知，皮肤生理学以及对周围刺激的敏感性会随着年龄的增长而降低，但很少有人认识到，中枢介导的机制允许在处理这些周围输入和与外部环境相互作用时维持相同程度的功能。为了证明这个概念，我们对 18 岁至 70 岁的受试者的处理速度、敏感性（阈值）、辨别能力和适应指标进行了观察。结果表明，尽管反应速度和感觉阈值随着年龄而变化，但辨别能力和适应指标却没有变化。这些发现的意义在于，当中枢神经系统（CNS）受到损害时，类似的适应指标已被证明会发生显着变化。这种妥协已在患有自闭症、慢性疼痛、急性 NMDA 受体阻滞、脑震荡以及触觉-热相互作用的受试者群体中得到证实。如果适应指标与皮质可塑性平行，那么当前研究的结果表明，老龄化人群中的中枢神经系统仍然能够进行可塑性变化，并且这种皮质可塑性可能是补偿已知随着年龄自然发生的退化的机制。因此，这些定量测量——因为它们可以有效、客观地获得，并且似乎随着系统皮质改变而显着偏离正常值——可能是大脑皮质健康的有用指标。
While it is well known that skin physiology – and consequently sensitivity to peripheral stimuli – degrades with age, what is less appreciated is that centrally mediated mechanisms allow for maintenance of the same degree of functionality in processing these peripheral inputs and interacting with the external environment. In order to demonstrate this concept, we obtained observations of processing speed, sensitivity (thresholds), discriminative capacity, and adaptation metrics on subjects ranging in age from 18 to 70. The results indicate that although reaction speed and sensory thresholds change with age, discriminative capacity, and adaptation metrics do not. The significance of these findings is that similar metrics of adaptation have been demonstrated to change significantly when the central nervous system (CNS) is compromised. Such compromise has been demonstrated in subject populations with autism, chronic pain, acute NMDA receptor block, concussion, and with tactile–thermal interactions. If the metric of adaptation parallels cortical plasticity, the results of the current study suggest that the CNS in the aging population is still capable of plastic changes, and this cortical plasticity could be the mechanism that compensates for the degradations that are known to naturally occur with age. Thus, these quantitative measures – since they can be obtained efficiently and objectively, and appear to deviate from normative values significantly with systemic cortical alterations – could be useful indicators of cerebral cortical health.
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DOI：
10.1523/jneurosci.3252-09.2009
发表时间：
2009-12-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM
通讯作者：
Dale AM
DOI：
10.1093/geronj/41.6.732
发表时间：
1986-11-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
KENSHALO, DR
通讯作者：
KENSHALO, DR
影响因子：
4.8
作者：
Kattenstroth, Jan-Christoph;Kolankowska, Izabella;Dinse, Hubert R.
通讯作者：
Dinse, Hubert R.
影响因子：
2.5
作者：
Friedman, Robert M.;Chen, Li Min;Roe, Anna W.
通讯作者：
Roe, Anna W.
DOI：
10.1093/geronb/57.2.p101
发表时间：
2002-03-01
影响因子：
6.2
作者：
Hultsch, DF;MacDonald, SWS;Dixon, RA
通讯作者：
Dixon, RA