Genome-Wide Analysis of the Distinct Types of Chromatin Interactions in Arabidopsis thaliana
Genome-Wide Analysis of the Distinct Types of Chromatin Interactions in Arabidopsis thaliana
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拟南芥染色质相互作用不同类型的全基因组分析
DOI：
10.1093/pcp/pcw194
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发表时间：
2016-11
影响因子：
4.9
通讯作者：
Chen Ming
中科院分区：
文献类型：
--
作者：
Wang Jingjing;Zhou Yincong;Li Xue;Meng Xianwen;Fan Miao;Chen Hongjun;Xue Jitong;Chen Ming
染色体的三维形状调节基因表达和基因组功能。我们对染色质相互作用的作用的了解正在迅速发展。在这里，我们介绍了拟南芥中全球染色质相互作用模式的研究。你好
The three-dimensional shapes of chromosomes regulate gene expression and genome function. Our knowledge of the role of chromatin interaction is evolving rapidly. Here, we present a study of global chromatin interaction patterns in Arabidopsis thaliana. High-throughput experimental techniques have been developed to map long-range interactions within chromatin. We have integrated data from multiple experimental sources including Hi-C, BS-seq, ChIP-chip and ChIP-seq data for 17 epigenetic marks and 35 transcription factors. We identified seven groups of interacting loci, which can be distinguished by their epigenetic profiles. Furthermore, the seven groups of interacting loci can be divided into three types of chromatin linkages based on expression status. We observed that two interacting loci sometimes share common epigenetic and transcription factor-binding profiles. Different groups of loci display very different relationships between epigenetic marks and the binding of transcription factors. Distinctive types of chromatin linkages exhibit different gene expression profiles. Our study unveils an entirely unexplored regulatory interaction, linking epigenetic profiles, transcription factor binding and the three-dimensional spatial organization of the Arabidopsis nuclear genome.
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DOI：
10.1089/clinomi.02.02.05
发表时间：
2015-09
期刊：
Clinical OMICs
影响因子：
--
作者：
C. Anderson
通讯作者：
C. Anderson
DOI：
10.1146/annurev-cellbio-101011-155824
发表时间：
2012
影响因子：
11.3
作者：
Van Bortle K;Corces VG
通讯作者：
Corces VG
影响因子：
64.8
作者：
Jin, Fulai;Li, Yan;Dixon, Jesse R.;Selvaraj, Siddarth;Ye, Zhen;Lee, Ah Young;Yen, Chia-An;Schmitt, Anthony D.;Espinoza, Celso A.;Ren, Bing
通讯作者：
Ren, Bing
影响因子：
48
作者：
Langmead, Ben;Salzberg, Steven L.
通讯作者：
Salzberg, Steven L.
小鼠基因组的空间组织及其在复发性染色体易位中的作用。
影响因子：
64.5
作者：
Zhang Y;McCord RP;Ho YJ;Lajoie BR;Hildebrand DG;Simon AC;Becker MS;Alt FW;Dekker J
通讯作者：
Dekker J