Microglial/Macrophage polarization and function in brain injury and repair after stroke.
Microglial/Macrophage polarization and function in brain injury and repair after stroke.
复制标题
脑卒中后小胶质细胞/巨噬细胞极化与脑损伤修复功能。
DOI：
10.1111/cns.13620
复制
发表时间：
2021-05
影响因子：
5.5
通讯作者：
Jiang X
中科院分区：
文献类型：
--
作者：
Lyu J;Xie D;Bhatia TN;Leak RK;Hu X;Jiang X
中风是致残和死亡的主要原因，治疗选择有限。脑卒中损伤后，小胶质细胞和中枢神经系统巨噬细胞被迅速激活并调节神经病理过程，引导功能恢复过程。为了加速这种恢复，小胶质细胞可以吞噬死亡细胞并清除不可修复的受损组织，从而创造一个更适合形成新神经回路的微环境。此外，单核细胞来源的巨噬细胞穿过受损的血脑屏障，渗透到受伤的大脑。髓系细胞在脑损伤和修复中的具体功能是多种多样的，并且依赖于表型极化状态。然而，入侵中枢神经系统的巨噬细胞在多大程度上占据了与中枢神经系统小胶质细胞不同的功能壁龛，仍有待确定。本文综述了小胶质细胞在发育和成人大脑中的生理特征和功能。我们还回顾了(a)卒中后小胶质细胞和巨噬细胞的激活和表型极化，(b)控制极化状态的分子机制，以及(c)小胶质细胞对脑病理和修复的贡献。最后，我们总结了目前在卒中后校准小胶质细胞/巨噬细胞反应的治疗策略方面的突破。本文综述了小胶质细胞与脑卒中相关的研究进展，重点介绍了小胶质细胞/巨噬细胞表型极化及其在脑损伤和修复中的功能。它还回顾了小胶质细胞在发育和成人大脑中的生理特征和功能，并描述了目前在卒中后校准小胶质细胞/巨噬细胞反应的治疗策略方面的突破。
Stroke is a leading cause of disability and mortality, with limited treatment options. After stroke injury, microglia and CNS‐resident macrophages are rapidly activated and regulate neuropathological processes to steer the course of functional recovery. To accelerate this recovery, microglia can engulf dying cells and clear irreparably‐damaged tissues, thereby creating a microenvironment that is more suitable for the formation of new neural circuitry. In addition, monocyte‐derived macrophages cross the compromised blood‐brain barrier to infiltrate the injured brain. The specific functions of myeloid lineage cells in brain injury and repair are diverse and dependent on phenotypic polarization statuses. However, it remains to be determined to what degree the CNS‐invading macrophages occupy different functional niches from CNS‐resident microglia. In this review, we describe the physiological characteristics and functions of microglia in the developing and adult brain. We also review (a) the activation and phenotypic polarization of microglia and macrophages after stroke, (b) molecular mechanisms that control polarization status, and (c) the contribution of microglia to brain pathology versus repair. Finally, we summarize current breakthroughs in therapeutic strategies that calibrate microglia/macrophage responses after stroke. The present review summarizes recent advances in microglial research in relation to stroke with emphases on microglial/macrophage phenotypic polarization and function in brain injury and repair. It also reviews the physiological characteristics and functions of microglia in the developing and adult brain, and describes current breakthroughs in therapeutic strategies that calibrate microglia/macrophage responses after stroke.
登录
查看更多内容
小胶质细胞增强了共培养 RMEC 的血管生成、迁移和增殖。
影响因子：
2
作者：
Ding X;Gu R;Zhang M;Ren H;Shu Q;Xu G;Wu H
通讯作者：
Wu H
影响因子：
8
作者：
Cai, Wei;Dai, Xuejiao;Chen, Jun
通讯作者：
Chen, Jun
影响因子：
9.3
作者：
Pena-Philippides JC;Caballero-Garrido E;Lordkipanidze T;Roitbak T
通讯作者：
Roitbak T
DOI：
10.1073/pnas.0803945105
发表时间：
2008-11-25
影响因子：
11.1
作者：
Breckwoldt, Michael O.;Chen, John W.;Weissleder, Ralph
通讯作者：
Weissleder, Ralph
影响因子：
2.4
作者：
Choi JY;Kim JY;Kim JY;Park J;Lee WT;Lee JE
通讯作者：
Lee JE