Beta genus papillomaviruses and skin cancer.

Beta genus papillomaviruses and skin cancer.
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DOI:
10.1016/j.virol.2015.02.004
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发表时间:
2015-05
期刊:
影响因子:
3.7
通讯作者:
Pfister, Herbert J.
Pfister, Herbert J.
中科院分区:
医学3区
文献类型:
--
作者:
Howley, Peter M.;Pfister, Herbert J.

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β属HPV在角质形成细胞癌(KC)中的作用仍有待确定。在这篇文章中,我们研究了β HPV在癌症中的潜在作用,这些病毒与KC相关的流行病学揭示了这些病毒,并得到了β HPV蛋白的致癌特性的支持。与癌症相关的α属HPV不同,其中转录活性病毒基因组总是被发现与癌症相关,β属HPV和角质形成细胞癌的情况并非如此。因此,β HPV在KC中的作用必然是在致癌起始中,而不是在肿瘤的维持中。
A role for the beta genus HPVs in keratinocyte carcinoma (KC) remains to be established. In this article we examine the potential role of the beta HPVs in cancer revealed by the epidemiology associating these viruses with KC and supported by oncogenic properties of the beta HPV proteins. Unlike the cancer associated alpha genus HPVs, in which transcriptionally active viral genomes are invariably found associated with the cancers, that is not the case for the beta genus HPVs and keratinocyte carcinomas. Thus a role for the beta HPVs in KC would necessarily be in the carcinogenesis initiation and not in the maintenance of the tumor.
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