Complement receptor 1 genetic variants contribute to the susceptibility to gastric cancer in chinese population.
Complement receptor 1 genetic variants contribute to the susceptibility to gastric cancer in chinese population.
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DOI：
10.7150/jca.10749
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发表时间：
2015
影响因子：
3.9
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Zhao L;Zhang Z;Lin J;Cao L;He B;Han S;Zhang X
1型补体受体(CR1/CD35)作为C3b/C4b的受体，在补体活性的调节中发挥重要作用，并进一步参与肿瘤的发生。本研究旨在阐明CR1基因变异与中国人群胃癌易感性的关系。以NCBI数据库为基础，用Haploview软件筛选出13个标记单核苷酸多态(SNPs)，并用iPlex金基因分型和Sequenom Massarray对500例胃癌患者和500例健康对照进行基因分型。用Logistic回归估计优势比(OR)和95%可信区间(CI)，以评估每个SNP与胃癌的相关性。在所有选定的标签SNPs中，CR1 rs9429942 T>；C被发现与患胃癌的风险有关。与携带rs9429942基因的携带者相比，携带CT基因的携带者患胃癌的风险降低88%，OR(95%CI)为0.12(0.03~0.50)。广义多因素降维分析显示rs75422544C>；A、rs10494885C>；T和rs7525160G>；C在胃癌发生发展过程中存在显著的三向交互作用，最大检验平衡准确率为56.07%，交叉验证一致性为7/10(P=0.011)。综上所述，我们的研究结果证实了CR1基因在中国人群胃癌发生发展中的遗传作用。
As the receptor for C3b/C4b, type 1 complement receptor (CR1/CD35) plays an important role in the regulation of complement activity and is further involved in carcinogenesis. This study aimed to elucidate the association of CR1 genetic variants with the susceptibility to gastric cancer in Chinese population. Based on the NCBI database, totally 13 tag single nucleotide polymorphisms (SNPs) were selected by Haploview program and genotyped using iPlex Gold Genotyping Assay and Sequenom MassArray among 500 gastric cancer cases and 500 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression to evaluate the association of each SNP with gastric cancer. Of all selected Tag SNPs , CR1 rs9429942 T > C was found to confer to the risk of developing gastric cancer. Compared with the carriers with rs9429942 TT genotype, those with CT genotype had 88% decreased risk of developing gastric cancer with OR (95%CI) of 0.12 (0.03-0.50). Generalized multifactor dimensionality reduction (GMDR) analysis revealed a significant three-way interaction among rs75422544 C > A, rs10494885 C > T and rs7525160 G > C in the development of gastric cancer with a maximum testing balance accuracy of 56.07% and a cross-validation consistency of 7/10 (P = 0.011). In conclusion, our findings demonstrated the genetic role of CR1 gene in the development of gastric cancer in Chinese population.
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作者：
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通讯作者：
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