Impact of CCL2 and CCR2 chemokine/receptor deficiencies on macrophage recruitment and continuous glucose monitoring in vivo.
Impact of CCL2 and CCR2 chemokine/receptor deficiencies on macrophage recruitment and continuous glucose monitoring in vivo.
复制标题
DOI：
10.1016/j.bios.2016.06.026
复制
发表时间：
2016-12-15
影响因子：
12.6
通讯作者：
Kreutzer, Donald L.
中科院分区：
文献类型：
--
作者：
Klueh, Ulrike;Czajkowski, Caroline;Ludzinska, Izabela;Qiao, Yi;Frailey, Jackman;Kreutzer, Donald L.
The accumulation of macrophages (MΦ) at the sensor-tissue interface is thought to be a major player in controlling tissue reactions and sensor performance in vivo. Nevertheless until recently no direct demonstration of the causal relationship between MΦ aggregation and loss of sensor function existed. Using a Continuous Glucose Monitoring (CGM) murine model we previously demonstrated that genetic deficiencies of MΦ or depletion of MΦ decreased MΦ accumulation at sensor implantation sites, which led to significantly enhanced CGM performance, when compared to normal mice. Additional studies in our laboratories have also demonstrated that MΦ can act as “metabolic sinks” by depleting glucose levels at the implanted sensors in vitro and in vivo. In the present study we extended these observations by demonstrating that MΦ chemokine (CCL2) and receptor (CCR2) knockout mice displayed a decrease in inflammation and MΦ recruitment at sensor implantation sites, when compared to normal mice. This decreased MΦ recruitment significantly enhanced CGM performance when compared to control mice. These studies demonstrated the importance of the CCL2 family of chemokines and related receptors in MΦ recruitment and sensor performance and suggest chemokine targets for enhancing CGM in vivo.
登录
查看更多内容
影响因子：
9.7
作者：
Moore, Laura Beth;Sawyer, Andrew J.;Charokopos, Antonios;Skokos, Eleni A.;Kyriakides, Themis R.
通讯作者：
Kyriakides, Themis R.
影响因子：
9.5
作者：
Luu TU;Gott SC;Woo BW;Rao MP;Liu WF
通讯作者：
Liu WF
影响因子：
12.6
作者：
Avula, M.;Jones, D.;Solzbacher, F.
通讯作者：
Solzbacher, F.
影响因子：
5.4
作者：
Klueh, Ulrike;Liu, Zenghe;Kreutzer, Don
通讯作者：
Kreutzer, Don
影响因子：
4.9
作者：
Norton, L. W.;Koschwanez, H. E.;Reichert, W. M.
通讯作者：
Reichert, W. M.