Biomarkers in Neuropsychiatric Systemic Lupus Erythematosus: A Systematic Literature Review of the Last Decade.
Biomarkers in Neuropsychiatric Systemic Lupus Erythematosus: A Systematic Literature Review of the Last Decade.
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神经精神系统性红斑狼疮的生物标志物：过去十年的系统文献综述。
DOI：
10.3390/brainsci12020192
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发表时间：
2022-01-30
期刊：
影响因子：
3.3
通讯作者：
Parodis I
中科院分区：
文献类型：
--
作者：
Lindblom J;Mohan C;Parodis I
SLE患者的神经系统受累，称为神经精神性SLE（NPSLE），构成了诊断的挑战，其管理仍然很差的优化。本文综述了近十年来NPSLE诊断、监测和预后的实验室生物标志物的最新进展。在Medline和Web of Science中进行了初步系统检索，以指导文章的选择。在NPSLE中显示出令人满意的区分NPSLE和对照的能力的新兴诊断生物标志物包括血清白细胞介素（IL）-6，microRNA（miR）-23 α，miR-155和脑脊液（CSF）α-Klotho。CSF脂质运载蛋白-2、巨噬细胞集落刺激因子（M-CSF）和免疫球蛋白（IG）M也在两个不同种族的队列中显示出这种能力。最近报道，血清干扰素（IFN）-α和神经元特异性烯醇化酶（NSE）与活动性NPSLE患者的疾病活动性中度相关。CSF IL-8、IL-13和粒细胞集落刺激因子（G-CSF）作为NPSLE患者治疗反应的预测因子，具有极好的敏感性，但特异性较差。总体上缺乏跨多个和不同队列的验证研究，需要进一步和协调一致的调查。尽管如此，我们提出CSF脂质运载蛋白2是有希望作为NPSLE可靠诊断生物标志物的分子之一。
Nervous system involvement in patients with SLE, termed neuropsychiatric SLE (NPSLE), constitutes a diagnostic challenge, and its management is still poorly optimised. This review summarises recent insights over the past decade in laboratory biomarkers of diagnosis, monitoring, and prognosis of NPSLE. An initial systematic search in the Medline and Web of Science was conducted to guide the selection of articles. Emerging diagnostic biomarkers in NPSLE that displayed satisfactory ability to discriminate between NPSLE and controls include serum interleukin (IL)-6, microRNA (miR)-23a, miR-155, and cerebrospinal fluid (CSF) α-Klotho. CSF lipocalin-2, macrophage colony-stimulating factor (M-CSF), and immunoglobulin (Ig)M also displayed such ability in two ethnically diverse cohorts. Serum interferon (IFN)-α and neuron specific enolase (NSE) were recently reported to moderately correlate with disease activity in patients with active NPSLE. CSF IL-8, IL-13, and granulocyte colony-stimulating factor (G-CSF) exhibited excellent sensitivity, yet poorer specificity, as predictors of response to therapy in patients with NPSLE. The overall lack of validation studies across multiple and diverse cohorts necessitates further and well-concerted investigations. Nevertheless, we propound CSF lipocalin 2 among molecules that hold promise as reliable diagnostic biomarkers in NPSLE.
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影响因子：
11.2
作者：
Chakraborty, Subhankar;Kaur, Sukhwinder;Guha, Sushovan;Batra, Surinder K.
通讯作者：
Batra, Surinder K.
影响因子：
27.4
作者：
Hanly JG;Urowitz MB;Su L;Bae SC;Gordon C;Wallace DJ;Clarke A;Bernatsky S;Isenberg D;Rahman A;Alarcón GS;Gladman DD;Fortin PR;Sanchez-Guerrero J;Romero-Diaz J;Merrill JT;Ginzler E;Bruce IN;Steinsson K;Khamashta M;Petri M;Manzi S;Dooley MA;Ramsey-Goldman R;Van Vollenhoven R;Nived O;Sturfelt G;Aranow C;Kalunian K;Ramos-Casals M;Zoma A;Douglas J;Thompson K;Farewell V;Systemic Lupus International Collaborating Clinics (SLICC)
通讯作者：
Systemic Lupus International Collaborating Clinics (SLICC)
影响因子：
4.2
作者：
Abraham CR;Chen C;Cuny GD;Glicksman MA;Zeldich E
通讯作者：
Zeldich E
影响因子：
--
作者：
Hanly, J. G.;Urowitz, M. B.;Merrill, J. T.
通讯作者：
Merrill, J. T.
影响因子：
0.9
作者：
Bassiouni, Sherine A.;Abdeen, Hanaa M.;Gharbia, Ola M.
通讯作者：
Gharbia, Ola M.