Prospective analysis of neuropsychiatric events in an international disease inception cohort of patients with systemic lupus erythematosus.
Prospective analysis of neuropsychiatric events in an international disease inception cohort of patients with systemic lupus erythematosus.
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DOI：
10.1136/ard.2008.106351
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发表时间：
2010-03
影响因子：
27.4
通讯作者：
Systemic Lupus International Collaborating Clinics (SLICC)
中科院分区：
文献类型：
--
作者：
Hanly JG;Urowitz MB;Su L;Bae SC;Gordon C;Wallace DJ;Clarke A;Bernatsky S;Isenberg D;Rahman A;Alarcón GS;Gladman DD;Fortin PR;Sanchez-Guerrero J;Romero-Diaz J;Merrill JT;Ginzler E;Bruce IN;Steinsson K;Khamashta M;Petri M;Manzi S;Dooley MA;Ramsey-Goldman R;Van Vollenhoven R;Nived O;Sturfelt G;Aranow C;Kalunian K;Ramos-Casals M;Zoma A;Douglas J;Thompson K;Farewell V;Systemic Lupus International Collaborating Clinics (SLICC)
旨在确定大型 SLE 患者初始队列 3 年内神经精神 (NP) 事件的频率、发生率、归因和结果以及对生活质量的影响。该研究由系统性狼疮国际合作诊所进行。患者在 SLE 诊断后 15 个月内入组。使用 ACR 病例定义来识别 NP 事件，并得出决策规则以确定可归因于 SLE 的 NP 疾病的比例。记录 NP 事件的结果并由 SF-36 确定患者感知的影响。共有 1206 名患者（89.6% 为女性），平均年龄 (±SD) 为 34.5±13.2 岁。入组时的平均病程为 5.4±4.2 个月。在平均 1.9±1.2 年的随访中，486/1206 (40.3%) 例患者出现 ≥1 次 NP 事件，使用两个先验决策规则，13.0%–23.6% 的患者归因于 SLE。个别 NP 事件的发生频率从 47.1%（头痛）到 0%（重症肌无力）不等。对于那些归因于 SLE 的 NP 事件，结果明显更好，特别是如果它们发生在 SLE 诊断后 1.5 年内。在研究中，患有 NP 事件的患者，无论归因如何，其心理和身体健康总分均显着较低。 SLE 患者中的 NP 事件发生频率各不相同，最常见于病程早期，并随着时间的推移对患者的生活质量产生不利影响。归因于非 SLE 原因的事件比 SLE 原因引起的事件更常见，尽管后者具有更有利的结果。
To determine the frequency, accrual, attribution and outcome of neuropsychiatric (NP) events and impact on quality of life over 3 years in a large inception cohort of SLE patients. The study was conducted by the Systemic Lupus International Collaborating Clinics. Patients were enrolled within 15 months of SLE diagnosis. NP events were identified using the ACR case definitions and decision rules were derived to determine the proportion of NP disease attributable to SLE. The outcome of NP events was recorded and patient perceived impact determined by the SF-36. There were 1206 patients (89.6% female) with a mean (±SD) age of 34.5±13.2 years. The mean disease duration at enrollment was 5.4±4.2 months. Over a mean follow-up of 1.9±1.2 years 486/1206 (40.3%) patients had ≥1 NP events which were attributed to SLE in 13.0%–23.6% of patients using two a priori decision rules. The frequency of individual NP events varied from 47.1% (headache) to 0% (myasthenia gravis). The outcome was significantly better for those NP events attributed to SLE especially if they occurred within 1.5 years of the diagnosis of SLE. Patients with NP events, regardless of attribution, had significantly lower summary scores for both mental and physical health over the study. NP events in SLE patients are variable in frequency, most commonly present early in the disease course and adversely impact patients’ quality of life over time. Events attributed to non-SLE causes are more common than those due to SLE, although the latter have a more favourable outcome.
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影响因子：
5.9
作者：
Karassa, FB;Ioannidis, JPA;Moutsopoulos, HM
通讯作者：
Moutsopoulos, HM
影响因子：
--
作者：
Hanly, J. G.;Urowitz, M. B.;Merrill, J. T.
通讯作者：
Merrill, J. T.
影响因子：
158.5
作者：
MCCUNE, WJ;GOLBUS, J;FOX, DA
通讯作者：
FOX, DA
影响因子：
--
作者：
Karlson, EW;Liang, MH;Daltroy, LH
通讯作者：
Daltroy, LH
影响因子：
--
作者：
Hanly, JG;Cassell, K;Fisk, JD
通讯作者：
Fisk, JD